Topological Characterization of Human and Mouse m⁵C Epitranscriptome Revealed by Bisulfite Sequencing

Figure 8

RNA m⁵C status is positively correlated with RNA half-life. In the above figure, each red dot represents a gene that carries m⁵C sites, and each blue dot represents a gene that does not carry an m⁵C site. When comparing the methylated and unmethylated genes of similar expression, the genes that carry an m⁵C site have longer RNA half-life than those that do not carry m⁵C sites. (a) Positive correlation between RNA methylation status and RNA half-life is observed in mouse brain ( value = 0.0374, generalized linear model of binomial family). (b) Positive correlation between RNA methylation status and RNA half-life is observed in mouse embryo stem cells (, generalized linear model of binomial family).