Gene Variation of Endoplasmic Reticulum Aminopeptidases 1 and 2, and Risk of Blood Pressure Progression and Incident Hypertension among 17,255 Initially Healthy Women
Table 3
Cox regression analysis for all SNPs evaluated with incident hypertension.
dbSNP
MA
MAF
HR
Lower 95% CI
Upper 95% CI
-uncorrected
ERAP1
rs1559085
G
0.1413
0.997
0.957
1.037
0.8652
rs27851
G
0.0607
1.008
0.951
1.069
0.7869
rs3756623
C
0.0750
1.011
0.959
1.065
0.6970
rs754615
C
0.3907
0.996
0.968
1.025
0.7774
rs1862609
A
0.3129
0.990
0.961
1.021
0.5240
rs27772
G
0.3133
0.986
0.956
1.016
0.3421
rs28081
A
0.1510
1.011
0.973
1.051
0.5739
rs27037
A
0.2957
1.026
0.995
1.058
0.0967
rs27429
C
0.0598
1.008
0.95
1.070
0.7860
rs27524
A
0.3730
1.029
1.000
1.059
0.0537
rs25862
A
0.4488
0.992
0.965
1.021
0.5849
rs11135480
C
0.1321
1.021
0.980
1.064
0.3230
rs10515247
A
0.1323
1.021
0.980
1.064
0.3261
rs149078
A
0.2965
0.999
0.969
1.030
0.9572
rs27042
A
0.3655
0.996
0.968
1.026
0.8056
rs27044
G
0.2795
1.013
0.982
1.045
0.4108
rs17482078
A
0.2039
0.980
0.947
1.015
0.2539
rs42398
G
0.1470
1.009
0.970
1.050
0.6454
rs469783
G
0.4374
1.032
1.003
1.062
0.0291
rs10050860
A
0.2127
0.964
0.931
0.997
0.0351
rs13154629
A
0.2131
0.973
0.940
1.007
0.1182
rs30187
A
0.3478
1.026
0.996
1.056
0.0914
rs27434
A
0.2175
1.026
0.992
1.062
0.1403
rs26618
G
0.2370
0.987
0.955
1.020
0.4313
rs25866
A
0.2341
1.015
0.982
1.050
0.3732
rs26653
C
0.2835
1.019
0.988
1.051
0.2330
rs34753
G
0.2796
1.016
0.985
1.048
0.3224
rs28129
G
0.2804
1.016
0.985
1.048
0.3149
rs18036
G
0.2441
1.000
0.968
1.033
0.9944
rs152280
A
0.2085
1.013
0.978
1.048
0.4764
rs12520537
G
0.1537
1.028
0.989
1.068
0.1629
rs41135
G
0.4669
0.981
0.953
1.009
0.1740
rs34736
A
0.0648
1.001
0.945
1.060
0.9785
ERAP2
rs2911132
A
0.3726
0.986
0.958
1.015
0.3506
rs2042381
A
0.2733
1.010
0.979
1.042
0.5209
rs2927615
A
0.2404
0.958
0.927
0.990
0.0107
rs2927612
G
0.1168
0.991
0.949
1.036
0.6977
rs2549778
A
0.4292
0.998
0.970
1.026
0.8664
rs6861666
G
0.0781
1.028
0.976
1.082
0.2971
rs3733904
G
0.2117
0.991
0.957
1.026
0.6043
rs2549779
G
0.4880
0.994
0.966
1.022
0.6693
rs4869315
A
0.4241
0.987
0.960
1.016
0.3795
rs2549782
C
0.4093
1.019
0.991
1.048
0.1873
rs17408150
T
0.0560
1.046
0.985
1.111
0.1450
rs7714122
G
0.0648
1.030
0.974
1.090
0.2986
Adjusted for age, body mass index, history of diabetes, history of hyperlipidemia, current smoking, exercise, alcohol use, education level, current hormone use, and randomized treatment assignment. MA = minor; MAF = minor allele frequency; HR = hazard ratio; CI = confidence interval.
