Meta-Analysis of Genome-Wide Association Studies Identifies Novel Functional CpG-SNPs Associated with Bone Mineral Density at Lumbar Spine

Table 3

The top ten most significant GO terms enriched for BMD-associated CpG-SNPs.

GOID	Term	Log odds ratio	value
GO:0072659	Protein localization to plasma membrane	5.42	4.06E − 16
GO:1990778	Protein localization to cell periphery	5.42	4.06E − 16
GO:0007009	Plasma membrane organization	4.96	3.08E − 14
GO:0035023	Regulation of Rho protein signal transduction	4.57	1.21E − 12
GO:0046578	Regulation of Ras protein signal transduction	4.01	1.96E − 10
GO:0072657	Protein localization to membrane	3.94	3.45E − 10
GO:0010256	Endomembrane system organization	3.93	3.75E − 10
GO:0000904	Cell morphogenesis involved in differentiation	2.92	4.50E − 08
GO:0051056	Regulation of small GTPase-mediated signal transduction	3.29	7.92E − 08
GO:0008295	Spermidine biosynthetic process	7.99	2.55E − 07

Note: GO enrichment analysis was performed in candidate genes annotated to BMD-associated CpG-SNPs ( value < 1.0 × 10⁻⁴).