Research Article

Systems Pharmacology-Based Approach of Connecting Disease Genes in Genome-Wide Association Studies with Traditional Chinese Medicine

Table 2

GWAS disease-TCM gene pairs with identified from this study.

TCM nameDiseases (Z-score)

1β-HydroxyalantolactoneOvarian cysts (3.952), ovarian diseases (3.365)
Ainsliadimer ANeoplasms, glandular and epithelial (4.051)
ArtemisininDiabetes mellitus, type 1 (4.526)
BenzoylaconitineEmbolism and thrombosis (5.058)
Benzyl benzoateEmbolism and thrombosis (6.157)
Berberine hydrochlorideCentral nervous system infections (4.626) hemorrhage (5.090), hypertension, pregnancy-induced (4.347), prion diseases (5.433)
BorneolEmbolism and thrombosis (4.754)
BritaninCentral nervous system infections (5.323), prion diseases (4.554)
Bruceine DIntestinal diseases (3.126), lip diseases (4.480), lymphoproliferative disorders (3.190), mouth abnormalities (4.471), skin diseases, papulosquamous (4.167)
BufalinLip diseases (12.748), mouth abnormalities (12.730), skin diseases, papulosquamous (6.010), spinal diseases (5.987)
ChelerythrineAutoimmune diseases of the nervous system (3.526)
Cholic acidEmbolism and thrombosis (4.536)
CinnamaldehydeEmbolism and thrombosis (4.559)
Cinnamic acidEmbolism and thrombosis (5.398)
CurculigosideHypersensitivity, immediate (3.676)
DaidzinAutoimmune diseases of the nervous system (4.358), bone marrow diseases (5.015), demyelinating autoimmune diseases, cns (3.744)
Deoxycholic acidEmbolism and thrombosis (5.072)
Four mixtureAutoimmune diseases of the nervous system (3.198), breast diseases (4.159), breast neoplasms (4.137), demyelinating autoimmune diseases, cns (3.263), gastrointestinal neoplasms (3.648), lymphoproliferative disorders (4.073), neoplasms, glandular and epithelial (3.244)
GamabufatalinGastroenteritis (4.344), skin diseases, papulosquamous (5.028)
GentiopicrosideBreast diseases (4.249), breast neoplasms (4.251)
Ginsenoside Rb2Embolism and thrombosis (4.604)
Ginsenoside Rb3Embolism and thrombosis (5.758)
Ginsenoside RcEmbolism and thrombosis (6.291)
Ginsenoside RdEmbolism and thrombosis (5.214)
Ginsenoside ReEmbolism and thrombosis (5.722)
Ginsenoside Rg1Skin diseases, papulosquamous (4.279)
IsoborneolEmbolism and thrombosis (4.441)
Japonicone AAcneiform eruptions (3.354), arthritis, rheumatoid (3.591), breast diseases (4.482), breast neoplasms (4.473), central nervous system infections (4.303), cocaine-related disorders (3.625), digestive system neoplasms (3.370), gastrointestinal neoplasms (5.216), intestinal diseases (3.592), leukemia (3.687), lymphoma (4.369), lymphoproliferative disorders (4.066), neoplasms, glandular and epithelial (3.772), ovarian diseases (3.535), prion diseases (5.863), rheumatic diseases (3.599), sebaceous gland diseases (3.357), urinary bladder diseases (3.722), urologic neoplasms (3.506)
LiquiritinAutoimmune diseases of the nervous system (3.704), glucose metabolism disorders (4.245), hypersensitivity, immediate (3.993)
NarciclasineBone marrow diseases (3.974), gastroenteritis (3.703), intestinal diseases (3.734), lymphoma (3.848), lymphoproliferative disorders (4.190), osteitis deformans (3.623), peripheral vascular diseases (3.707), prion diseases (4.772), skin diseases, papulosquamous (4.086)
Nitidine chlorideArthritis (3.319), bone marrow diseases (3.701), breast diseases (5.287), breast neoplasms (5.259), diabetes mellitus, type 2 (5.288), digestive system neoplasms (3.605), gastrointestinal neoplasms (3.712), glucose metabolism disorders (5.115), intestinal diseases (3.572), lymphoproliferative disorders (3.936), neoplasms, glandular and epithelial (4.427)
Notoginsenoside R1Ovarian cysts (4.713), ovarian diseases (4.526)
Oleanic acidBreast diseases (3.698), breast neoplasms (3.681), digestive system neoplasms (3.838), gastrointestinal neoplasms (4.394), muscular diseases (4.916), myositis (4.915), neoplasms (5.028)
OstholeNeoplasms (5.137)
SalidrosideAutoimmune diseases of the nervous system (3.615), hypersensitivity, immediate (3.817), neoplasms (4.994)
SanguinarineBreast diseases (4.521), breast neoplasms (4.535)
SantoninBreast neoplasms (3.506), gastrointestinal neoplasms (3.576)
Schisantherin AHypersensitivity, immediate (3.660)
Tanshinone IIABody weight (3.665), central nervous system infections (4.831), prion diseases (5.608)
TetrahydropalmatineAutoimmune diseases of the nervous system (4.315), demyelinating autoimmune diseases, cns (3.999), hypersensitivity, immediate (3.792)