Ensemble Methods with Voting Protocols Exhibit Superior Performance for Predicting Cancer Clinical Endpoints and Providing More Complete Coverage of Disease-Related Genes

Table 9

Reliability of selected mRNAs.

Names	Data scale	Reliable/Hits/ShareNum
		10	30	50	100
BRCA	5	0	1/2/2	1/2/2	4/5/5
	4	4/4/4	4/5/5	8/9/10	13/17/25
	3	0/2/4	2/6/13	5/10/21	13/21/45
	2	0/0/2	5/6/16	8/12/26	18/29/42
	1	8/10/18	27/33/49	39/58/85	68/97/156
	Total	12/16/28	39/52/85	61/91/144	116/169/273
	Hits/Total	57.1%	61.2%	63.2%	61.9%
	Reliable/Hits	75%	75%	67%	68.6%
KIRC	5	0	0	0	0/0/2
	4	0	0/0/3	0/0/3	2/4/8
	3	2/2/2	2/2/6	4/6/14	12/17/28
	2	2/2/6	10/17/22	19/27/34	26/40/71
	1	15/18/32	31/42/76	45/63/128	98/129/232
	Total	19/22/40	43/61/107	68/96/179	138/190/341
	Hits/Total	55%	57%	53.6%	55.7%
	Reliable/Hits	86.4%	70.5%	70.8%	72.6%
OV	5	0	1/1/1	1/1/2	2/2/5
	4	1/1/1	0/1/2	2/3/7	2/4/16
	3	0/0/1	1/1/8	1/2/16	12/16/55
	2	0/2/9	5/8/27	6/10/34	14/18/43
	1	7/8/25	13/21/59	27/34/96	50/64/160
	Total	8/11/36	20/32/97	37/50/155	80/104/279
	Hits/Total	35%	33%	33.3%	37.3%
	Reliable/Hits	72.7	62.5%	74%	76.9%

The table that records the hits and reliability in the “Human Protein Atlas” database. The “ShareNum” is the same in Table 8, and the “Hits” is the number of mRNAs recorded in the “Human Protein Atlas” database. The “Reliable” is the number of reliable hits. The reliability is measured by using the associated record in the “reliability (IH)” table. An mRNA is considered reliable only if the record is “approved” or “supported.” “Hits/Total” and “Reliable/Hits” are calculated simply by using the row “Total” for division. For example, the last two elements in the last column are 37.3% and 76.9%. They are calculated by the element in the associated row in “Total,” such as 80/104/279, where 37.3% = 104/279 and 76.9% = 80/104. The subdatasets from the OV-miRNA group have at most 83 microRNAs, and thus, the scale “100” of OV means 83.