Discovery of Novel Caeridins from the Skin Secretion of the Australian White’s Tree Frog, Litoria caerulea

Figure 9

Membrane permeabilisation of E. coli treated with Caeridin-a1, Caeridin-1, S5-Caeridin-1, melittin, and bradykinin. The hydrolysis of ONPG generated by the release of cytoplasmic β-galactosidase of E. coli after treatment at MIC and MBC of Caeridin-a1, MIC and MBC of melittin, and maximum tested concentration of Caeridin-1, S5-Caeridin-1, and bradykinin was measured spectroscopically at 420 nm UV for 30 min. Each point represents mean absorbance and SEM of three independent experiments and each experiment with five replicates.