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International Journal of Genomics
Volume 2018, Article ID 9025841, 12 pages
https://doi.org/10.1155/2018/9025841
Research Article

Metabolic Pathway Genes Associated with Susceptibility Genes to Coronary Artery Disease

1Department of Cardiovascular Surgery, Union Hospital, Fujian Medical University, Fuzhou, China
2Department of Nephrology, Union Hospital, Fujian Medical University, Fuzhou, China

Correspondence should be addressed to Linlin Li; moc.anis@7991bbil

Received 4 September 2017; Revised 15 November 2017; Accepted 4 December 2017; Published 11 February 2018

Academic Editor: Margarita Hadzopoulou-Cladaras

Copyright © 2018 Heng Lu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Coronary artery disease (CAD) is one of the leading threats to global health. Previous research has proven that metabolic pathway disorders, such as high blood lipids and diabetes, are one of the risk factors that mostly cause CAD. However, the crosstalk between metabolic pathways and CAD was mostly studied on physiology processes by analyzing a single gene function. A canonical correlation analysis was used to identify the metabolic pathways, which were integrated as a unit to coexpress with CAD susceptibility genes, and to resolve additional metabolic factors that are related to CAD. Seven pathways, including citrate cycle, ubiquinone, terpenoid quinone biosynthesis, and N-glycan biosynthesis, were identified as an integrated unit coexpressed with CAD genes. These pathways could not be revealed as a coexpressed pathway through traditional methods as each single gene has weak correlation. Furthermore, sets of genes in these pathways were candidate markers for diagnosis and detection from patients’ serum.