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International Journal of Genomics
Volume 2018, Article ID 9469670, 11 pages
https://doi.org/10.1155/2018/9469670
Research Article

Multitarget Effects of Danqi Pill on Global Gene Expression Changes in Myocardial Ischemia

1School of Life Sciences, Beijing University of Chinese Medicine, Beijing 100029, China
2Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China
3School of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China
4Staidson (Beijing) Biopharmaceuticals Co., Ltd., Beijing 100176, China

Correspondence should be addressed to Chun Li; moc.361@40205891nuhcil and Yong Wang; moc.anis@gnoygnaw_rotcod

Received 16 June 2017; Revised 27 August 2017; Accepted 18 September 2017; Published 1 February 2018

Academic Editor: Martine A. Collart

Copyright © 2018 Qiyan Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. M. Dai, S. Zhang, K. P. Chen, W. Hua, F. Z. Wang, and X. Chen, “Prognostic factors affecting the all-cause death and sudden cardiac death rates of post myocardial infarction patients with low left ventricular ejection fraction,” Chinese Medical Journal, vol. 122, no. 7, pp. 802–806, 2009. View at Google Scholar
  2. L. C. Slobbe, O. A. Arah, A. de Bruin, and G. P. Westert, “Mortality in Dutch hospitals: trends in time, place and cause of death after admission for myocardial infarction and stroke. An observational study,” BMC Health Services Research, vol. 8, no. 1, p. 52, 2008. View at Publisher · View at Google Scholar · View at Scopus
  3. H. Brønnum-Hansen, T. Jørgensen, M. Davidsen et al., “Survival and cause of death after myocardial infarction: the Danish MONICA study,” Journal of Clinical Epidemiology, vol. 54, no. 12, pp. 1244–1250, 2001. View at Publisher · View at Google Scholar · View at Scopus
  4. P. T. O'Gara, F. G. Kushner, D. D. Ascheim et al., “2013 ACCF/AHA guideline for the management of ST-elevation myocardial infarction: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines,” Circulation, vol. 127, no. 4, pp. e362–e425, 2013. View at Publisher · View at Google Scholar · View at Scopus
  5. H. Chang, Q. Wang, T. Shi et al., “Effect of DanQi pill on PPARα, lipid disorders and arachidonic acid pathway in rat model of coronary heart disease,” BMC Complementary and Alternative Medicine, vol. 16, no. 1, p. 103, 2016. View at Publisher · View at Google Scholar · View at Scopus
  6. Y. Wang, C. Li, Z. Liu et al., “DanQi pill protects against heart failure through the arachidonic acid metabolism pathway by attenuating different cyclooxygenases and leukotrienes B4,” BMC Complementary and Alternative Medicine, vol. 14, no. 1, p. 67, 2014. View at Publisher · View at Google Scholar · View at Scopus
  7. K. Takahashi, X. Ouyang, K. Komatsu et al., “Sodium tanshinone IIA sulfonate derived from Danshen (Salvia miltiorrhiza) attenuates hypertrophy induced by angiotensin II in cultured neonatal rat cardiac cells,” Biochemical Pharmacology, vol. 64, no. 4, pp. 745–750, 2002. View at Publisher · View at Google Scholar · View at Scopus
  8. J. Y. Han, J. Y. Fan, Y. Horie et al., “Ameliorating effects of compounds derived from Salvia miltiorrhiza root extract on microcirculatory disturbance and target organ injury by ischemia and reperfusion,” Pharmacology & Therapeutics, vol. 117, no. 2, pp. 280–295, 2008. View at Publisher · View at Google Scholar · View at Scopus
  9. Y. Y. Jiang, L. Wang, L. Zhang et al., “Characterization, antioxidant and antitumor activities of polysaccharides from Salvia miltiorrhiza Bunge,” International Journal of Biological Macromolecules, vol. 70, pp. 92–99, 2014. View at Publisher · View at Google Scholar · View at Scopus
  10. Y. Zhang, X. Li, and Z. Wang, “Antioxidant activities of leaf extract of Salvia miltiorrhiza Bunge and related phenolic constituents,” Food and Chemical Toxicology, vol. 48, no. 10, pp. 2656–2662, 2010. View at Publisher · View at Google Scholar · View at Scopus
  11. A. Mortazavi, B. A. Williams, K. McCue, L. Schaeffer, and B. Wold, “Mapping and quantifying mammalian transcriptomes by RNA-Seq,” Nature Methods, vol. 5, no. 7, pp. 621–628, 2008. View at Publisher · View at Google Scholar · View at Scopus
  12. Z. Wang, M. Gerstein, and M. Snyder, “RNA-Seq: a revolutionary tool for transcriptomics,” Nature Reviews Genetics, vol. 10, no. 1, pp. 57–63, 2009. View at Publisher · View at Google Scholar · View at Scopus
  13. Y. Wang, C. Li, Y. Ouyang et al., “Cardioprotective effects of Qishenyiqi mediated by angiotensin II type 1 receptor blockade and enhancing angiotensin-converting enzyme 2,” Evidence-based Complementary and Alternative Medicine, vol. 2012, Article ID 978127, 9 pages, 2012. View at Publisher · View at Google Scholar · View at Scopus
  14. Y. Wang, Z. Liu, C. Li et al., “Drug target prediction based on the herbs components: the study on the multitargets pharmacological mechanism of qishenkeli acting on the coronary heart disease,” Evidence-based Complementary and Alternative Medicine, vol. 2012, Article ID 698531, 10 pages, 2012. View at Publisher · View at Google Scholar · View at Scopus
  15. M. D. Robinson, D. J. McCarthy, and G. K. Smyth, “edgeR: a bioconductor package for differential expression analysis of digital gene expression data,” Bioinformatics, vol. 26, no. 1, pp. 139-140, 2010. View at Publisher · View at Google Scholar · View at Scopus
  16. W. Huang da, B. T. Sherman, and R. A. Lempicki, “Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists,” Nucleic Acids Research, vol. 37, no. 1, pp. 1–13, 2009. View at Publisher · View at Google Scholar · View at Scopus
  17. L. A. Bovolenta, M. L. Acencio, and N. Lemke, “HTRIdb: an open-access database for experimentally verified human transcriptional regulation interactions,” BMC Genomics, vol. 13, no. 1, p. 405, 2012. View at Publisher · View at Google Scholar · View at Scopus
  18. M. E. Smoot, K. Ono, J. Ruscheinski, P. L. Wang, and T. Ideker, “Cytoscape 2.8: new features for data integration and network visualization,” Bioinformatics, vol. 27, no. 3, pp. 431-432, 2011. View at Publisher · View at Google Scholar · View at Scopus
  19. Q. Wang, C. Li, Q. Zhang et al., “The effect of Chinese herbs and its effective components on coronary heart disease through PPARs-PGC1α pathway,” BMC Complementary and Alternative Medicine, vol. 16, no. 1, p. 514, 2016. View at Publisher · View at Google Scholar · View at Scopus
  20. Y. Wang, C. Li, Q. Wang et al., “Danqi pill regulates lipid metabolism disorder induced by myocardial ischemia through FATP-CPTI pathway,” BMC Complementary and Alternative Medicine, vol. 15, no. 1, p. 28, 2015. View at Publisher · View at Google Scholar · View at Scopus
  21. Y. Zhang, H. Wang, L. Cui et al., “Continuing treatment with Salvia miltiorrhiza injection attenuates myocardial fibrosis in chronic iron-overloaded mice,” PLoS One, vol. 10, no. 4, article e0124061, 2015. View at Publisher · View at Google Scholar · View at Scopus
  22. X. Y. Ji, B. K. Tan, and Y. Z. Zhu, “Salvia miltiorrhiza and ischemic diseases,” Acta Pharmacologica Sinica, vol. 21, no. 12, pp. 1089–1094, 2000. View at Google Scholar
  23. J. Sun, S. Hong Huang, B. K. H. Tan et al., “Effects of purified herbal extract of Salvia miltiorrhiza on ischemic rat myocardium after acute myocardial infarction,” Life Sciences, vol. 76, no. 24, pp. 2849–2860, 2005. View at Publisher · View at Google Scholar · View at Scopus
  24. S. Y. Han, H. X. Li, X. Ma et al., “Evaluation of the anti-myocardial ischemia effect of individual and combined extracts of Panax notoginseng and Carthamus tinctorius in rats,” Journal of Ethnopharmacology, vol. 145, no. 3, pp. 722–727, 2013. View at Publisher · View at Google Scholar · View at Scopus
  25. S. Chen, J. Liu, X. Liu et al., “Panax notoginseng saponins inhibit ischemia-induced apoptosis by activating PI3K/Akt pathway in cardiomyocytes,” Journal of Ethnopharmacology, vol. 137, no. 1, pp. 263–270, 2011. View at Publisher · View at Google Scholar · View at Scopus
  26. J. W. Guo, L. M. Li, G. Q. Qiu et al., “Effects of Panax notoginseng saponins on ACE2 and TNF-alpha in rats with post-myocardial infarction-ventricular remodeling,” Zhong Yao Cai, vol. 33, no. 1, pp. 89–92, 2010. View at Google Scholar
  27. J. Chen, F. Wang, F. S. C. Lee, X. Wang, and M. Xie, “Separation and identification of water-soluble salvianolic acids from Salvia miltiorrhiza Bunge by high-speed counter-current chromatography and ESI-MS analysis,” Talanta, vol. 69, no. 1, pp. 172–179, 2006. View at Publisher · View at Google Scholar · View at Scopus
  28. J. B. Wan, C. M. Lai, S. P. Li, M. Y. Lee, L. Y. Kong, and Y. T. Wang, “Simultaneous determination of nine saponins from Panax notoginseng using HPLC and pressurized liquid extraction,” Journal of Pharmaceutical and Biomedical Analysis, vol. 41, no. 1, pp. 274–279, 2006. View at Publisher · View at Google Scholar
  29. M. R. Richards, J. D. Harp, D. S. Ory, and J. E. Schaffer, “Fatty acid transport protein 1 and long-chain acyl coenzyme a synthetase 1 interact in adipocytes,” Journal of Lipid Research, vol. 47, no. 3, pp. 665–672, 2006. View at Publisher · View at Google Scholar · View at Scopus
  30. E. M. Maier, B. Liebl, W. Röschinger et al., “Population spectrum of ACADM genotypes correlated to biochemical phenotypes in newborn screening for medium-chain acyl-CoA dehydrogenase deficiency,” Human Mutation, vol. 25, no. 5, pp. 443–452, 2005. View at Publisher · View at Google Scholar · View at Scopus
  31. G. L. Brower, S. P. Levick, and J. S. Janicki, “Inhibition of matrix metalloproteinase activity by ACE inhibitors prevents left ventricular remodeling in a rat model of heart failure,” American Journal of Physiology-Heart and Circulatory Physiology, vol. 292, no. 6, pp. H3057–H3064, 2007. View at Publisher · View at Google Scholar · View at Scopus
  32. G. K. Asimakis, S. Lick, and C. Patterson, “Postischemic recovery of contractile function is impaired in SOD2+/− but not SOD1+/− mouse hearts,” Circulation, vol. 105, no. 8, pp. 981–986, 2002. View at Publisher · View at Google Scholar · View at Scopus
  33. M. Ohashi, M. S. Runge, F. M. Faraci, and D. D. Heistad, “MnSOD deficiency increases endothelial dysfunction in ApoE-deficient mice,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 26, no. 10, pp. 2331–2336, 2006. View at Publisher · View at Google Scholar · View at Scopus
  34. B. Jiang, D. Li, Y. Deng et al., “Salvianolic acid A, a novel matrix metalloproteinase-9 inhibitor, prevents cardiac remodeling in spontaneously hypertensive rats,” PLoS One, vol. 8, no. 3, article e59621, 2013. View at Publisher · View at Google Scholar · View at Scopus
  35. G. R. Zhao, H. M. Zhang, T. X. Ye et al., “Characterization of the radical scavenging and antioxidant activities of danshensu and salvianolic acid B,” Food and Chemical Toxicology, vol. 46, no. 1, pp. 73–81, 2008. View at Publisher · View at Google Scholar · View at Scopus
  36. C. Y. Li, W. Deng, X. Q. Liao, J. Deng, Y. K. Zhang, and D. X. Wang, “The effects and mechanism of ginsenoside Rg1 on myocardial remodeling in an animal model of chronic thromboembolic pulmonary hypertension,” European Journal of Medical Research, vol. 18, no. 1, p. 16, 2013. View at Publisher · View at Google Scholar · View at Scopus
  37. C. H. Lee and J. H. Kim, “A review on the medicinal potentials of ginseng and ginsenosides on cardiovascular diseases,” Journal of Ginseng Research, vol. 38, no. 3, pp. 161–166, 2014. View at Publisher · View at Google Scholar · View at Scopus