Multitarget Effects of Danqi Pill on Global Gene Expression Changes in Myocardial Ischemia
Table 2
Significantly enriched KEGG pathways among upregulated and downregulated genes in ischemic heart. The pathways are ranked according to the order of the increasing values. Gene count referred to the number of genes among all the pathway member genes.
KEGG pathway ID and name
Gene count
value
Upregulated
rno04610: complement and coagulation cascades
11
4.59E − 07
rno04670: leukocyte transendothelial migration
9
0.001
rno05322: systemic lupus erythematosus
8
0.001
rno04510: focal adhesion
11
0.003
rno04512: ECM-receptor interaction
7
0.004
rno05200: pathways in cancer
14
0.005
rno05414: dilated cardiomyopathy
7
0.006
Downregulated
rno00071: fatty acid metabolism
6
7.55E − 05
rno00280: valine, leucine, and isoleucine degradation
6
1.18E − 04
rno00620: pyruvate metabolism
5
7.45E − 04
rno03320: PPAR signaling pathway
6
9.11E − 04
rno00330: arginine and proline metabolism
4
0.018834
rno00020: citrate cycle (TCA cycle)
3
0.04066
rno05412: arrhythmogenic right ventricular cardiomyopathy
4
0.044529
rno00640: propanoate metabolism
3
0.048358
rno00071: fatty acid metabolism
6
7.55E − 05
rno00280: valine, leucine, and isoleucine degradation
