Multitarget Effects of Danqi Pill on Global Gene Expression Changes in Myocardial Ischemia

Table 5

Enriched upregulated pathways and biological processes by DQP treatment.

Term	%	value	Genes
KEGG pathway
Carbon metabolism	7.5	0.000027	ME1, ALDOA, GOT2, ME3, ACADM, ENO3, SUCLA2
Biosynthesis of antibiotics	6.5	0.004	ALDOA, GOT2, ACADM, ENO3, SUCLA2, HADHB
Metabolic pathways	15.1	0.008	NDUFA4, ALDOA, ME1, ME3, ACADM, CHKB, UQCRFS1, HADHB, GOT2, ACSL1, CKM, MCCC1, ENO3, SUCLA2
Fatty acid degradation	3.2	0.023	ACSL1, ACADM, HADHB
Fatty acid metabolism	3.2	0.030	ACSL1, ACADM, HADHB
Valine, leucine, and isoleucine degradation	3.2	0.031	ACADM, MCCC1, HADHB
GO_biological process
Pyruvate metabolic process	3.2	0.001	ME1, ME3, PFKFB2
Response to hormone	5.4	0.001	ME1, BDNF, ACADM, ADRA1B, UQCRFS1
Response to drug	8.6	0.013	BDNF, ACSL1, ACADM, ADRA1B, ENO3, AQP7, UQCRFS1, SOD2
Glycolytic process	3.2	0.015	ALDOA, PFKFB2, ENO3
Negative regulation of fat cell differentiation	3.2	0.021	VEGFA, INSIG1, SOD2
Regulation of synaptic plasticity	3.2	0.021	BDNF, PSEN2, RAPGEF2
Muscle contraction	3.2	0.024	TRDN, MYOM2, TMOD4
Response to cold	3.2	0.026	ACADM, VEGFA, SOD2
Intraciliary transport involved in cilium morphogenesis	2.2	0.033	IFT81, PCM1
Oxidation-reduction process	8.6	0.036	ME1, NDUFA4, ME3, ACADM, L2HGDH, UQCRFS1, OXR1, HADHB