International Journal of Genomics / 2019 / Article / Tab 3

Research Article

Computational Identification of Metabolic Pathways of Plasmodium falciparum using the -Shortest Path Algorithm

Table 3

Reactions with the centrality score above the specified level of significance.

Reaction IDReaction nameEC numberBiological processCentrality scoreReference

HBDG_cHemoglobin digestionCysteine and methionine0.521053
T_c_to_a_C00073L-Methionine transport reactionCysteine and methionine0.442105
R00896_cL-Cysteine:2-oxoglutarate aminotransferase2.6.1.1Cysteine and methionine0.426316
T_c_to_r_C006411,2-Diacyl-sn-glycerol transport reactionGlycerolipid0.409357
R02251_rAcyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase2.3.1.20Glycerolipid pathway0.324619
T_c_to_r_C006411,2-Diacyl-sn-glycerol transport reactionGlycerophospholipid pathway0.42986
R00177_cATP:L-methionine S-adenosyltransferase2.5.1.6Glycerophospholipid pathway0.264179Oyelade et al. [12]
R02037_R06868
_R06869_c
S-Adenosyl-L-methionine:(methyl)ethanolamine-phosphate N-methyltransferase2.1.1.103Glycerophospholipid pathway0.255603Choubey et al. [40], Pessi et al. [41], Witola et al. [42]
R00497_cGamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)6.3.2.3Glycine, serine and threonine0.287619Chiappino-Pepe et al. [18], Huthmacher et al. [39]
R01061_cD-Glyceraldehyde-3-phosphate:NAD+ oxidoreductase (phosphorylating)1.2.1.12 1.2.1.59Glycolysis pathway0.552381
R01068_cD-Fructose-1,6-bisphosphate D-glyceraldehyde-3-phosphate-lyase (glycerone-phosphate-forming)4.1.2.13Glycolysis pathway0.495238Wanidworanun et al. [43]
R00769_cUTP:D-fructose-6-phosphate 1-phosphotransferase2.7.1.11Glycolysis pathway0.490476
R03427_cInositol-1,4-bisphosphate 1-phosphatase3.1.3.57Inositol phosphate pathway0.533333
R04372_cPhosphatidylinositol-3,4-bisphosphate 4-phosphatase3.1.3.66Inositol phosphate pathway0.533333
R01187_c1D-Myo-inositol 3-phosphate phosphohydrolase3.1.3.25Inositol phosphate pathway0.47619
R01802_cCDP-diacylglycerol:myo-inositol 3-phosphatidyltransferase2.7.8.11Inositol phosphate pathway0.419048Chiappino-Pepe et al. [18], Fatumo et al. [44]
R03429_cInositol-1,3,4-trisphosphate 5/6-kinase2.7.1.159Inositol phosphate pathway0.285714
R01641_cSedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glycolaldehyde transferase2.2.1.1Pentose phosphate pathway0.328478
R00720_cInosine 5-triphosphate pyrophosphohydrolase3.6.1.8 3.6.1.19Purine metabolism0.448718
R01231_cXanthosine-5-phosphate:L-glutamine amido-ligase (AMP-forming)6.3.5.2Purine metabolism0.37833McConkey [46]
R00576_cGlutamine-pyruvate transaminase2.6.1.15Purine metabolism0.345098
R02024_c2-Deoxycytidine diphosphate:oxidized-thioredoxin 2-oxidoreductase1.17.4.1Purine metabolism0.340121Barker et al. [47], Chakrabarti et al. [48], Lytton et al. [49]
R01135_cIMP:L-aspartate ligase (GDP-forming)6.3.4.4Purine metabolism0.330982Eaazhisai et al. [50]
R00328_cGDP phosphohydrolase3.6.1.5; 3.6.1.6; 3.6.1.42Purine metabolism0.287731
R00570_cATP:CDP phosphotransferase2.7.4.6Pyrimidine0.45977Oyelade et al. [12], Chiappino-Pepe et al. [18]
R02024_c2-Deoxycytidine diphosphate:oxidized-thioredoxin 2-oxidoreductase1.17.4.1Pyrimidine0.419157Barker et al. [47], Chakrabarti et al. [48], Chiappino-Pepe et al. [18], Lytton et al. [49]
R00571_cUTP:ammonia ligase (ADP-forming)6.3.4.2Pyrimidine0.255172Chiappino-Pepe et al. [18]
R00573_cUTP:L-glutamine amido-ligase (ADP-forming)6.3.4.2Pyrimidine0.255172Chiappino-Pepe et al. [18]
R06517_cAcyl-CoA:sphingosine N-acyltransferase2.3.1.24Sphingolipid0.431917Gerold and Schwarz [32]
R02251_cAcyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase2.3.1.20Sphingolipid0.325708
R00351_mAcetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysis)2.3.3.1 2.3.3.3TCA0.377739
R02569_mAcetyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-acetyltransferase2.3.1.12TCA0.281995Chiappino-Pepe et al. [18]

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