Epigenetic and Neurological Impairments Associated with Early Life Exposure to Persistent Organic Pollutants

Figure 4

The three-hit hypothesis as initially presented by Daskalakis et al. in 2013. The first two hits in early life provide an epigenetically programmed quiescent or latent phase. Subsequent exposure to a third hit can “swing the balance” towards health or disease. Adapted from [123].