Research Article
Identification and Validation of Core Genes Involved in the Development of Papillary Thyroid Carcinoma via Bioinformatics Analysis
Table 2
Gene ontology analysis of differentially expressed genes in PTC.
| Expression | Category | ID | Term | Count | value |
| Downregulated | GOTERM_BP_FAT | GO:0007167 | Enzyme-linked receptor protein signaling pathway | 47 | 3.40E-08 | GOTERM_BP_FAT | GO:0007399 | Nervous system development | 80 | 8.50E-08 | GOTERM_BP_FAT | GO:0061061 | Muscle structure development | 34 | 1.20E-07 | GOTERM_BP_FAT | GO:0010517 | Regulation of phospholipase activity | 11 | 4.20E-07 | GOTERM_BP_FAT | GO:0040007 | Growth | 43 | 8.80E-07 | GOTERM_CC_FAT | GO:0005578 | Proteinaceous extracellular matrix | 31 | 1.50E-10 | GOTERM_CC_FAT | GO:0031012 | Extracellular matrix | 36 | 2.20E-09 | GOTERM_CC_FAT | GO:0044421 | Extracellular region part | 124 | 1.80E-07 | GOTERM_CC_FAT | GO:0005576 | Extracellular region | 137 | 2.50E-06 | GOTERM_CC_FAT | GO:0030018 | Z disc | 12 | 4.00E-05 | GOTERM_MF_FAT | GO:1901681 | Sulfur compound binding | 17 | 1.90E-05 | GOTERM_MF_FAT | GO:0005539 | Glycosaminoglycan binding | 16 | 2.00E-05 | GOTERM_MF_FAT | GO:0008201 | Heparin binding | 13 | 9.20E-05 | GOTERM_MF_FAT | GO:0005102 | Receptor binding | 49 | 4.30E-04 | GOTERM_MF_FAT | GO:0019199 | Transmembrane receptor protein kinase activity | 8 | 1.30E-03 |
| Upregulated | GOTERM_BP_FAT | GO:0030198 | Extracellular matrix organization | 35 | 2.10E-14 | GOTERM_BP_FAT | GO:0007155 | Cell adhesion | 85 | 2.90E-14 | GOTERM_BP_FAT | GO:2000026 | Regulation of multicellular organismal development | 78 | 6.70E-11 | GOTERM_BP_FAT | GO:0040011 | Locomotion | 70 | 6.10E-10 | GOTERM_BP_FAT | GO:0051094 | Positive regulation of developmental process | 56 | 8.80E-10 | GOTERM_CC_FAT | GO:0005576 | Extracellular region | 160 | 2.20E-10 | GOTERM_CC_FAT | GO:0044421 | Extracellular region part | 141 | 2.40E-10 | GOTERM_CC_FAT | GO:0031982 | Membrane-bounded vesicle | 115 | 3.80E-05 | GOTERM_CC_FAT | GO:0070062 | Extracellular exosome | 94 | 4.90E-05 | GOTERM_CC_FAT | GO:1903561 | Extracellular vesicle | 94 | 6.00E-05 | GOTERM_MF_FAT | GO:0005539 | Glycosaminoglycan binding | 20 | 7.60E-08 | GOTERM_MF_FAT | GO:0005102 | Receptor binding | 60 | 5.40E-07 | GOTERM_MF_FAT | GO:0050840 | Extracellular matrix binding | 10 | 1.30E-06 | GOTERM_MF_FAT | GO:0042802 | Identical protein binding | 54 | 6.00E-06 | GOTERM_MF_FAT | GO:0098772 | Molecular function regulator | 52 | 5.60E-05 |
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Abbreviations: GO: gene ontology; BP: biological process; MF: molecular function; CC: cellular component.
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