Genus-Wide Comparative Genomics Analysis of Neisseria to Identify New Genes Associated with Pathogenicity and Niche Adaptation of Neisseria Pathogens

Figure 6

COG enrichment analysis of SSR loci in NMS and NGS unique genes. Subplots (a) and (b) represent the UGNP gene set characteristics based on Neisseria gonorrhoeae and Neisseria meningitidis datasets, respectively. Subplot (c) represents the UGNGS gene set characteristics based on 15 Neisseria gonorrhoeae strains, and subplot (d) represents the UGNMS gene set characteristics based on Neisseria meningitidis strains. The red circular markers represent the average percentage of genes that enriched in the COG function categories (C–X) for each genome dataset. The blue inverted triangle markers represent the average number of SSR of each COG category gene for each genome dataset. The error bar represents the standard error of the mean for each gene group. Since the gene is absent from five COG categories (A, B, D, Y, and Z) in presented dataset, they have been omitted from the figures. Besides, the genes unassigned to any COG categories were combined into category S (function unknown). COG abbreviations: C: energy production and conversion; E: amino acid transport and metabolism; F: nucleotide transport and metabolism; G: carbohydrate transport and metabolism; H: coenzyme transport and metabolism; I: lipid transport and metabolism; J: translation, ribosomal structure, and biogenesis; K: transcription; L: replication, recombination, and repair; M: cell wall/membrane/envelope biogenesis; N: cell motility; O: posttranslational modification, protein turnover, and chaperones; P: inorganic ion transport and metabolism; Q: secondary metabolite biosynthesis, transport, and catabolism; R: general function prediction only; T: signal transduction mechanisms; U: intracellular trafficking, secretion, and vesicular transport; V: defense mechanisms; W: extracellular structures; X: mobilome: prophages, transposons; S: function unknown.

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