Correlation of TSHR and CTLA-4 Single Nucleotide Polymorphisms with Graves Disease

Table 3

Multifactor logistic regression analyzes the correlation of TSHR and CTLA-4 SNPs with GD.

	SNPs		Alleles		Dominant model		Recessive model		Homozygous model		Heterozygous model
			OR (95% CI)		OR (95% CI)		OR (95% CI)		OR (95% CI)		OR (95% CI)
TSHR	rs179247		G/A		GG+AG/AA		GG/AG+AA		GG/AA		AG/AA
	TP		0.57 (0.48, 0.68)	<0.001	0.50 (0.40, 0.63)	<0.001	0.50 (0.34, 0.73)	<0.001	0.37 (0.25, 0.55)	<0.001	0.54 (0.42, 0.68)	<0.001
	Sex	M	0.56 (0.38, 0.84)	0.005	0.57 (0.34, 0.95)	0.030	0.30 (0.11, 0.80)	0.016	0.25 (0.09, 0.69)	0.007	0.67 (0.39, 1.15)	0.148
		F	0.57 (0.47, 0.70)	<0.001	0.48 (0.37, 0.62)	<0.001	0.55 (0.36, 0.83)	0.005	0.40 (0.26, 0.62)	<0.001	0.51 (0.39, 0.66)	<0.001
	rs2284722		A/G		AA+AG/GG		AA/AG+GG		AA/GG		AG/GG
	TP		1.34 (1.12, 1.60)	0.001	1.33 (1.06, 1.67)	0.013	2.14 (1.34, 3.42)	0.002	2.33 (1.44, 3.78)	0.001	1.22 (0.96, 1.55)	0.097
	Sex	M	0.91 (0.61, 1.38)	0.669	0.90 (0.54, 1.51)	0.694	0.88 (0.34, 2.30)	0.797	0.85 (0.32, 2.28)	0.748	0.91 (0.53, 1.57)	0.744
		F	1.47 (1.21, 1.80)	<0.001	1.46 (1.14, 1.88)	0.003	2.79 (1.61, 4.83)	<0.001	3.15 (1.79, 5.53)	<0.001	1.31 (1.01, 1.70)	0.046
	rs12101261		C/T		CC+CT/TT		CC/CT+TT		CC/TT		CT/TT
	TP		0.58 (0.49, 0.69)	<0.001	0.53 (0.42, 0.66)	<0.001	0.44 (0.30, 0.63)	<0.001	0.34 (0.23, 0.50)	<0.001	0.59 (0.46, 0.75)	<0.001
	Sex	M	0.58 (0.40, 0.86)	0.006	0.54 (0.32, 0.90)	0.018	0.43 (0.18, 1.01)	0.053	0.34 (0.14, 0.82)	0.017	0.60 (0.35, 1.04)	0.066
		F	0.58 (0.48, 0.70)	<0.001	0.52 (0.41, 0.68)	<0.001	0.44 (0.29, 0.66)	<0.001	0.34 (0.22, 0.52)	<0.001	0.59 (0.45, 0.77)	<0.001
	rs4903964		G/A		GG+AG/AA		GG/AG+AA		GG/AA		AG/AA
	TP		0.58 (0.50, 0.69)	<0.001	0.57 (0.45, 0.71)	<0.001	0.38 (0.27, 0.54)	<0.001	0.31 (0.21, 0.45)	<0.001	0.67 (0.53, 0.86)	0.020
	Sex	M	0.60 (0.41, 0.87)	0.008	0.56 (0.33, 0.94)	0.027	0.46 (0.21, 0.98)	0.044	0.36 (0.16, 0.82)	0.014	0.64 (0.37, 1.10)	0.107
		F	0.58 (0.48, 0.70)	<0.001	0.57 (0.44, 0.74)	<0.001	0.37 (0.25, 0.54)	<0.001	0.30 (0.20, 0.45)	<0.001	0.68 (0.52, 0.90)	0.007
	rs2300525		C/T		CC+CT/TT		CC/CT+TT		CC/TT		CT/TT
	TP		1.18 (0.99, 1.40)	0.072	1.18 (0.95, 1.48)	0.143	1.34 (0.90, 2.01)	0.154	1.42 (0.93, 2.15)	0.101	1.14 (0.90, 1.44)	0.288
	Sex	M	0.92 (0.62, 1.36)	0.668	0.87 (0.53, 1.45)	0.600	0.98 (0.40, 2.39)	0.959	0.91 (0.36, 2.32)	0.849	0.87 (0.51, 1.47)	0.593
		F	1.25 (1.03, 1.52)	0.028	1.28 (0.99, 1.64)	0.058	1.45 (0.92, 2.29)	0.106	1.58 (0.99, 2.52)	0.055	1.22 (0.93, 1.59)	0.146
	rs17111394		C/T		CC+CT/TT		CC/CT+TT		CC/TT		CT/TT
	TP		1.29 (1.06, 1.57)	0.010	1.29 (1.02, 1.63)	0.031	1.66 (0.99, 2.78)	0.055	1.78 (1.05, 3.00)	0.031	1.22 (0.96, 1.56)	0.111
	Sex	M	1.02 (0.66, 1.57)	0.934	1.06 (0.63, 1.78)	0.834	0.88 (0.30, 2.60)	0.822	0.91 (0.30, 2.72)	0.865	1.06 (0.61, 1.82)	0.844
		F	1.37 (1.10, 1.70)	0.005	1.36 (1.05, 1.76)	0.021	1.99 (1.10, 3.59)	0.023	2.15 (1.18, 3.91)	0.012	1.26 (0.96, 1.66)	0.092
CTLA-4	rs231804		G/A		GG+AG/AA		GG/AG+AA		GG/AA		AG/AA
	TP		0.80 (0.64, 1.00)	0.054	0.77 (0.60, 1.00)	0.045	0.86 (0.41, 1.80)	0.680	0.80 (0.38, 1.86)	0.556	0.77 (0.59, 1.00)	0.050
	Sex	M	0.66 (0.39, 1.11)	0.116	0.69 (0.39, 1.23)	0.203	—	—	—	—	0.75 (0.42, 1.36)	0.346
		F	0.84 (0.66, 1.08)	0.176	0.80 (0.60, 1.05)	0.108	1.08 (0.50, 2.36)	0.845	1.01 (0.46, 2.21)	0.977	0.78 (0.58, 1.04)	0.086
	rs1024161		G/A		GG+AG/AA		GG/AG+AA		GG/AA		AG/AA
	TP		0.85 (0.71, 1.01)	0.065	0.82 (0.66, 1.03)	0.085	0.81 (0.54, 1.20)	0.293	0.75 (0.49, 1.13)	0.162	0.84 (0.66, 1.06)	0.145
	Sex	M	0.93 (0.62, 1.39)	0.712	0.94 (0.57, 1.57)	0.825	0.77 (0.27, 2.18)	0.617	0.76 (0.26, 2.22)	0.612	0.98 (0.58, 1.65)	0.929
		F	0.83 (0.68, 1.01)	0.065	0.79 (0.62, 1.02)	0.070	0.81 (0.53, 1.26)	0.351	0.74 (0.48, 1.16)	0.192	0.81 (0.62, 1.05)	0.112
	rs231726		G/A		GG+AG/AA		GG/AG+AA		GG/AA		AG/AA
	TP		0.83 (0.71, 0.99)	0.035	0.78 (0.62, 0.98)	0.031	0.83 (0.59, 1.18)	0.300	0.74 (0.52, 1.07)	0.108	0.79 (0.62, 1.01)	0.055
	Sex	M	0.76 (0.52, 1.12)	0.163	0.74 (0.44, 1.23)	0.248	0.62 (0.27, 1.41)	0.254	0.55 (0.23, 1.31)	0.177	0.79 (0.46, 1.36)	0.398
		F	0.85 (0.71, 1.03)	0.097	0.79 (0.61, 1.02)	0.067	0.89 (0.61, 1.30)	0.541	0.79 (0.53, 1.18)	0.252	0.79 (0.60, 1.03)	0.084
	rs10197319		T/C		TT+CT/CC		TT/CT+CC		TT/CC		CT/CC
	TP		0.85 (0.70, 1.03)	0.097	0.68 (0.54, 0.86)	0.001	0.85 (0.51, 1.43)	0.543	0.75 (0.44, 1.28)	0.291	0.67 (0.53, 0.86)	0.001
	Sex	M	0.94 (0.62, 1.45)	0.793	0.32 (0.18, 0.57)	<0.001	1.12 (0.29, 4.27)	0.872	0.78 (0.20, 3.03)	0.725	0.28 (0.15, 0.52)	<0.001
		F	0.83 (0.67, 1.03)	0.085	0.80 (0.62, 1.03)	0.080	0.81 (0.46, 1.43)	0.466	0.75 (0.42, 1.33)	0.319	0.80 (0.62, 1.05)	0.107

TP: total population; M: male; F: female; .