Correlation of TSHR and CTLA-4 Single Nucleotide Polymorphisms with Graves Disease
Table 5
The relationship between haplotypes and GD.
SNP
Haplotype
Case group
Control group
OR (95% CI)
%
%
rs179247
AGTA
224
37.6
200
32.2
1.27 (1.07, 1.50)
0.005
rs2284722
GGCG
127
21.3
203
32.7
0.56 (0.46, 0.67)
<0.001
rs12101261
AATA
168
28.2
132
21.3
1.45 (1.21, 1.75)
<0.001
rs4903964
AGTG
32
5.3
33
5.3
1.00 (0.70, 1.43)
0.997
AGCG
14
2.4
16
2.6
0.94 (0.57, 1.57)
0.820
GGCA
11
1.9
10
1.6
1.20 (0.66, 2.20)
0.548
AATG
6
1.0
8
1.3
0.76 (0.36, 1.64)
0.488
GACG
4
0.6
9
1.5
0.40 (0.18, 0.92)
0.031
rs2300525
TT
417
69.8
451
72.8
0.86 (0.73, 1.03)
0.105
rs17111394
CC
139
23.3
117
18.8
1.32 (1.08, 1.60)
0.006
CT
39
6.6
49
7.9
0.83 (0.61, 1.12)
0.223
rs231804
AAA
405
67.9
395
63.7
1.21 (1.02, 1.43)
0.029
rs1024161
GGG
81
13.5
102
16.4
0.80 (0.64, 1.00)
0.046
rs231726
AGG
79
13.2
83
13.4
0.98 (0.78, 1.24)
0.863
AAG
32
5.3
38
6.2
0.84 (0.60, 1.19)
0.323
Four of the eight haplotypes (composed of rs179247, rs2284722, rs12101261, and rs4903964) had frequencies greater than 0.03. There are four haplotypes (composed of rs231804, rs1024161, and rs231726) that had frequencies greater than 0.03. .
