Mutations in the ARAP3 Gene in Three Families with Primary Lymphedema Negative for Mutations in Known Lymphedema-Associated Genes

Table 4

Details of molecular interactions of Cys685 and Tyr685 of the modeled ARAP3 protein with adjacent interacting residues.

S. no.	Mutation	Amino acid	Molecular interactions observed	Bond length in angstroms	Bond type
1	Cys685Tyr	Cys685	Cys685:N-Ile682:O	3.09	H-bond
2			Arg690:N-Cys685:O	2.88	H-bond
3			Cys685-Arg690	4.88	Hydrophobic
4		Tyr685	Trp662:N-Tyr685:O	2.14	H-bond
5			Trp662:C-Tyr685:O	2.10	H-bond
6			Trp662:C-Tyr685:O	1.80	H-bond
7			Tyr685:N-Ile682:O	3.09	H-bond
8			Arg690:N-Tyr685:O	2.88	H-bond
9			Tyr685-Leu658	5.19	Pi interaction
10			Tyr685-Ile682	5.37	Pi interaction