Quantile-Dependent Expressivity of Serum Uric Acid Concentrations

Figure 4

Precision medicine perspective of genotype-specific uric acid differences (histogram inserts) vs. quantile-dependent expressivity perspective (line graphs showing larger genetic effect size when average uric acid concentrations were high) for (a) Yang et al. [51] 2020 report on the uric acid difference due to drinking more vs. less than 10 g/d of alcohol by major, heterozygotic (het), and minor alleles of the SLC2A9 rs3733591, PKD2 rs2725220, and ABCG2 rs2231142 haplotype; (b) Hamajima et al. [52] 2012 report on the uric acid difference between drinking >5 times per week vs. abstaining by the LRP2 rs2544390 genotypes; (c) Yang et al. [51] 2020 report on the uric acid difference due to consuming more vs. less than 6.3 g/d of chicken by major, heterozygotic (het), and minor alleles of the SLC2A9 rs3733591, PKD2 rs2725220, and ABCG2 rs2231142 haplotype; (d) Yang et al. [51] 2020 report on the uric acid difference due to consuming more vs. less than 3.0 g/d of processed meat by major, heterozygotic (het), and minor alleles of the SLC2A9 rs3733591, PKD2 rs2725220, and ABCG2 rs2231142 haplotype.