Modulation of the Wound Healing through Noncoding RNA Interplay and GSK-3β/NF-κB Signaling Interaction

Figure 1

Noncoding RNAs and NF-κB signaling pathway. Lipopolysaccharide (LPS), tumor necrosis factor-α (TNF-α), and C-X-C motif chemokine ligand 12 (CXCL12) can activate the NF-κB signaling pathway via the upregulation of IκB kinase (IKK). The noncoding RNAs that stimulate or inhibit the activation and cytoplasm-nucleus transport of NF-κB are shown in the figure. Consequently, these noncoding RNAs can be classified into proinflammatory noncoding RNAs and anti-inflammatory noncoding RNAs, according to their roles in the NF-κB signaling pathway.