International Journal of Genomics

Epigenetic Control of Reprogramming and Cellular Differentiation


Publishing date
03 Aug 2012
Status
Published
Submission deadline
03 Feb 2012

1Sanford-Burnham Institute for Medical Research, La Jolla, CA, USA

2Dulbecco Telethon Institute, Rome, Italy

3Fondazione EBRI-Santa Lucia, Rome, Italy

4Institute of Predictive and Personalized Medicine of Cancer (IMPPC), Barcelona, Spain


Epigenetic Control of Reprogramming and Cellular Differentiation

Description

The epigenetic regulation of gene transcription is emerging as key mechanism by which cells adopt discrete cellular phenotypes. This process is active during development and in adult life, but it also plays a crucial role during induced pluripotency, when coordinated gene repression and activation permits the acquisition of stem cell like phenotypes. Upstream and downstream effectors of epigenetic networks operating during cellular differentiation are the extrinsic signals (e.g., developmental or regenerating cues) and chromatin regulators (e.g., chromatin-modifying enzymes and noncoding RNAs), respectively. The coordinated activity of these effectors imparts a three-dimensional (3D) nuclear organization typical of specific cell types. The recent introduction of high-throughput technologies allows accurate genome-wide analysis of gene expression and is expanding our knowledge on how specific clusters of transcripts are selected during the activation of the diverse differentiation programs. Thus, the combined efforts between functional genomics and cellular biology will help to integrate our knowledge on the complex mechanisms that ensure the execution of the correct differentiation program.

In this issue, we invite researchers to submit research articles as well as review articles addressing how cellular differentiation can be explored integrating more conventional molecular and cellular biology approaches with novel high-throughput genome-wide analysis. Articles addressing the role of epigenetic regulation, nuclear structure, and genome architecture in regulating cellular processes such as stemness, reprogramming, differentiation, and aging are welcome. Potential topics include, but are not limited to:

  • Terminal differentiation during development and postnatal life
  • Overlapping and distinct pathways in differentiation and aging
  • Induced pluripotency and cellular plasticity

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/ijg/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2012
  • - Article ID 538639
  • - Editorial

Epigenetic Control of Reprogramming and Cellular Differentiation

Lucia Latella | Daniela Palacios | ... | Pier Lorenzo Puri
  • Special Issue
  • - Volume 2012
  • - Article ID 759407
  • - Review Article

A Systems Approach and Skeletal Myogenesis

Yoshiaki Ito | Tomohiro Kayama | Hiroshi Asahara
  • Special Issue
  • - Volume 2012
  • - Article ID 564381
  • - Review Article

Epigenetic Regulation of B Lymphocyte Differentiation, Transdifferentiation, and Reprogramming

Bruna Barneda-Zahonero | Lidia Roman-Gonzalez | ... | Maribel Parra
  • Special Issue
  • - Volume 2012
  • - Article ID 284786
  • - Research Article

Predictive Models of Gene Regulation from High-Throughput Epigenomics Data

Sonja Althammer | Amadís Pagès | Eduardo Eyras
  • Special Issue
  • - Volume 2012
  • - Article ID 836374
  • - Review Article

Turning on Myogenin in Muscle: A Paradigm for Understanding Mechanisms of Tissue-Specific Gene Expression

Herve Faralli | F. Jeffrey Dilworth
  • Special Issue
  • - Volume 2012
  • - Article ID 256892
  • - Review Article

Epigenetic Alterations in Muscular Disorders

Chiara Lanzuolo
  • Special Issue
  • - Volume 2012
  • - Article ID 979168
  • - Review Article

Tackling Skeletal Muscle Cells Epigenome in the Next-Generation Sequencing Era

Raffaella Fittipaldi | Giuseppina Caretti
  • Special Issue
  • - Volume 2012
  • - Article ID 434529
  • - Review Article

The Stability of the Induced Epigenetic Programs

Maria J. Barrero
International Journal of Genomics
 Journal metrics
Acceptance rate27%
Submission to final decision83 days
Acceptance to publication48 days
CiteScore2.030
Impact Factor2.303
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