International Journal of Genomics

Advancing Genomics for Drug Development and Safety Evaluation


Status
Published

Lead Editor
Guest Editors

1National Center for Toxicological Research, U.S. Food and Drug Administration, Jeffersonville, USA

2Sichuan University, Chengdu, China


Advancing Genomics for Drug Development and Safety Evaluation

Description

Genomics technologies have been widely applied to biomedical research. Taking advantage of emerging genomics technologies such as next generation sequencing (NGS), researchers could dive into detection and quantification of more aboard genomic elements (i.e., DNA, mRNA, miRNA, cirRNA, and lncRNA) to uncover the underlying diseases etiology and pathology. Furthermore, some findings and observations from the genomics space have successfully demonstrated the potential application to drug development.

We invite investigators to contribute original research articles as well as review or opinion articles that seek to address how the genomics advance drug development regarding efficacy, safety, and personalized design. A particular interest will be given to papers exploring or discussing the application of different genomic techniques such as RNAseq, DNAseq, and Mirseq to facilitate NGS-driven drug development.

Potential topics include but are not limited to the following:

  • Application of RNAseq/DNAseq/Mirseq for drug safety evaluation and biomarker discovery
  • Importance and significance of genomics for rare diseases and cancers
  • Uncovering molecular and cellular mechanism of drug induced toxicity with genomics technology
  • Integrated analysis of genomics data to address biomedical questions
  • Bioinformatics methodologies and pipelines for genomics data analysis
  • Analyses related to the safety assessment of drug carriers

Articles

  • Special Issue
  • - Volume 2018
  • - Article ID 3126820
  • - Editorial

Advancing Genomics for Drug Development and Safety Evaluation

Zhichao Liu | Joshua Xu | Zhining Wen
  • Special Issue
  • - Volume 2018
  • - Article ID 9784161
  • - Research Article

Classification of Complete Proteomes of Different Organisms and Protein Sets Based on Their Protein Distributions in Terms of Some Key Attributes of Proteins

Hao-Bo Guo | Yue Ma | ... | Hong Guo
  • Special Issue
  • - Volume 2018
  • - Article ID 8576890
  • - Review Article

Shiftwork-Mediated Disruptions of Circadian Rhythms and Sleep Homeostasis Cause Serious Health Problems

Suliman Khan | Pengfei Duan | ... | Hongwei Hou
  • Special Issue
  • - Volume 2018
  • - Article ID 8124950
  • - Research Article

Ensemble Methods with Voting Protocols Exhibit Superior Performance for Predicting Cancer Clinical Endpoints and Providing More Complete Coverage of Disease-Related Genes

Runyu Jing | Yu Liang | ... | Li He
  • Special Issue
  • - Volume 2017
  • - Article ID 3538568
  • - Research Article

A New Network-Based Strategy for Predicting the Potential miRNA-mRNA Interactions in Tumorigenesis

Jiwei Xue | Fanfan Xie | ... | Menglong Li
  • Special Issue
  • - Volume 2017
  • - Article ID 9264034
  • - Research Article

Uncover the Underlying Mechanism of Drug-Induced Myopathy by Using Systems Biology Approaches

Dong Li | Aixin Li | ... | Yang Teng
International Journal of Genomics
 Journal metrics
Acceptance rate35%
Submission to final decision76 days
Acceptance to publication31 days
CiteScore3.400
Impact Factor2.414
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