Table 5: Criteria for liver transplantation in acute liver failure (ALF).
(a) King’s College Criteria

Acetaminophen-induced ALFNonacetaminophen ALF

(1) Arterial pH < 7.3 irrespective of grade of encephalopathy(1) INR > 6.5 (PT > 100 sec), irrespective of grade of encephalopathy
OROR any 3 of the following:
(1) PT > 100 sec(1) INR > 3.5 (PT > 50 sec)
(2) Serum creatinine >3.4 mg/dL(2) Age < 10 or >40 years
(3) Stage 3 or 4 encephalopathy(3) Serum bilirubin >18 mg/dL
(4)  Jaundice to encephalopathy interval >7 days
(5)  Non-A, non-B hepatitis, idiosyncratic drug reaction

(b) Prognostic index in fulminant Wilsons hepatitis (WPI) [14]

Score01234

Serum bilirubin (reference range 3–20 mmol/L)<100100–150151–200201–300>300
Serum aspartate transaminase (reference range 7–40 IU/L)<100100–150151–200201–300>300
Prothrombin time prolongation (seconds)<44–89–1213–20>30

Patients with a WPI score ≥7 need urgent liver transplantation

(c) Revised Wilson prognostic index (RWPI) [15]

ScoreBilirubin (μmol/L)INRAST (IU/L)WCC (109/L)Albumin (g/L)

00–1000–1.290–1000–6.7>45
1101–1501.3–1.6101–1506.8–8.334–44
2151–2001.7–1.9151–3008.4–10.325–33
3201–3002.0–2.4301–40010.4–15.321–24
4≥301>2.5>401>15.4<20

Patients with a RWPI ≥11 needed urgent liver transplantation

(d) Clichy criteria (Hospital Paul-Brousse, Villejuif [16])

Hepatic encephalopathy, and factor V level:

<20% in patients <30 years of age, or
<30% in patients ≥30 years of age