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International Journal of Hepatology
Volume 2011, Article ID 841407, 10 pages
Review Article

Management of Hepatic Encephalopathy

1University College London Institute of Hepatology, The Royal Free Hospital, Pond Street, London NW3 2PF, UK
2Department of Gastroenterology, King Georges Hospital, Barley Lane, Goodmayes, Ilford, Essex IG3 8YB, UK

Received 28 April 2011; Accepted 8 June 2011

Academic Editor: Deepak Amarapurkar

Copyright © 2011 G. Wright et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Hepatic encephalopathy (HE), the neuropsychiatric presentation of liver disease, is associated with high morbidity and mortality. Reduction of plasma ammonia remains the central therapeutic strategy, but there is a need for newer novel therapies. We discuss current evidence supporting the use of interventions for both the general management of chronic HE and that necessary for more acute and advanced disease.