International Journal of Hepatology / 2012 / Article / Tab 2

Review Article

Fungal Infections: Their Diagnosis and Treatment in Transplant Recipients

Table 2

Pathogenic fungi and the antifungal agents in vitro activity**.

MicroorganismAntifungal agents
FluconazoleVoriconazolePosaconazoleEchinocandinPolyenes

Candida albicans1st line1st line1st line1st line1st line
Candida glabrataUnknown3rd line3rd line1st line2nd line
Candida tropicalis1st line1st line1st line1st line1st line

Candida parapsilosis1st line1st line1st line2nd line1st line
Candida kruseiNo activity2nd line2nd line1st line2nd line
Candida guilliermondii1st line1st line1st line2nd line2nd line

Candida lusitaniae3rd line2nd line2nd line2nd line2nd line
Cryptococcus neoformans1st line1st line1st lineNo activity1st line
Aspergillus fumigatusNo activity1st line1st line2nd line2nd line
Aserpgillus flavusNo activity1st line1st line2nd line2nd line

Aspergillus terreusNo activity1st line1st line2nd lineNo activity
Fusarium sp.No activity2nd line2nd lineNo activity2nd line
Scedosporium apiospermumNo activity1st line1st lineUnknownUnknown

Scedosporium prolificansNo activityUnknownUnknownNo activityUnknown
Trichosporon spp.Unknown2nd line2nd lineNo activity3rd line
Zygomycetes (e.g., Absidia, Mucor, and Rhizopus)No activityNo activity1st lineNo activity1st line
Dematiaceous molds
(e.g., Alternaria,  Bipolaris,  Curvularia,  and Exophiala)
Unknown1st line1st line3rd line3rd line

Dimorphic Fungi
 Blastomyces  dermatitidis3rd line2nd line2nd lineNo activity1st line
 Coccidioides  immitis1st line2nd line2nd lineNo activity1st line
 Histoplasma  capsulatum3rd line2nd line2nd lineNo activity1st line
 Sporothrix  schenckii3rd line2nd line2nd lineNo activity1st line

**Echinocandins, voriconazole, posaconazole, and polyenes have poor urine penetration.

We are committed to sharing findings related to COVID-19 as quickly as possible. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. Review articles are excluded from this waiver policy. Sign up here as a reviewer to help fast-track new submissions.