Cell Signals Influencing Hepatic Fibrosis

<table>Activation of Hepatic Stellate cells following TLR4 and TGF<svg height="13.425" id="M212" style="vertical-align:-2.29482pt" version="1.1" viewbox="0 0 8.8500004 13.425" width="8.8500004" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,13.425)">
<g transform="translate(72,-61.26)">
<text transform="matrix(1,0,0,-1,-71.95,63.6)">
<tspan style="font-size: 12.50px; " x="0" y="0">𝛽</tspan>
</text>
</g>
</g>
</svg> Receptor cross-talk. In aHSCS, Bambi blocks TGF<svg height="13.425" id="M213" style="vertical-align:-2.29482pt" version="1.1" viewbox="0 0 8.8500004 13.425" width="8.8500004" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,13.425)">
<g transform="translate(72,-61.26)">
<text transform="matrix(1,0,0,-1,-71.95,63.6)">
<tspan style="font-size: 12.50px; " x="0" y="0">𝛽</tspan>
</text>
</g>
</g>
</svg>R activation. TLR4 activation by LPS downregulates BAMBI, so that TGF<svg height="13.425" id="M214" style="vertical-align:-2.29482pt" version="1.1" viewbox="0 0 8.8500004 13.425" width="8.8500004" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,13.425)">
<g transform="translate(72,-61.26)">
<text transform="matrix(1,0,0,-1,-71.95,63.6)">
<tspan style="font-size: 12.50px; " x="0" y="0">𝛽</tspan>
</text>
</g>
</g>
</svg>1 now induces signal transductions of phosphorylated Smad2/3 and activation of collagen Type I production in HSCs.</table>

International Journal of Hepatology

Cell Signals Influencing Hepatic Fibrosis

Figure 5