Paraoxonase Activity and Expression Is Modulated by Therapeutics in Experimental Rat Nonalcoholic Fatty Liver Disease
Figure 3
PON2 and PON3 mRNA expression in rat fatty liver experimental model. Fatty liver in Sprague-Dawley rats was induced by methionine-choline-deficient diet (MCDD) for 9 weeks. Rats were treated for other 6 weeks with rosiglitazone (R); metformin (M); rosiglitazone + metformin in combination (R+M); ezetimibe (E); valsartan (V); rosiglitazone + metformin + valsartan in combination (R+M+V) or rosiglitazone + metformin + valsartan + ezetimibe (R+M+V+E). 18 s ribosomal RNA was used for relative quantification. “#” indicates versus control group (fed by standard rat chow). “*” indicates versus MCDD group.
