Potential Antioxidant Role of Tridham in Managing Oxidative Stress against Aflatoxin-B₁-Induced Experimental Hepatocellular Carcinoma

Table 4

Effect of TD on nonenzymic antioxidants and thiols in liver of control and experimental animals.

Parameters	Group I (control)	Group II (AFB1 induced)	Group III (AFB1 induced + TD)	Group IV (TD alone)
Vitamin C	3.93±0.49	1.95±0.27^a∗	3.69±0.43^b∗	4.11±0.51^cNS
Vitamin E	2.54±0.35	1.36±0.17^a∗	2.38±0.28^b∗	2.45±0.31^cNS
Total thiols (TSHs)	9.42±1.13	4.68±0.56^a∗	8.81±1.14^b∗	9.31±1.11^cNS
Non protein thiols (NPSHs)	5.58±0.66	2.15±0.25^a∗	5.31±0.68^b∗	5.44±0.65^cNS
Reduced glutathione (GSH)	32.31±4.21	18.34±2.77^a∗	29.73±4.75^b∗	33.83±4.17^cNS

Units: GSH mg/100 g tissue, Vitamin C and E mg/g wet tissue, TSH and NPSH: μg/mg protein. Values are expressed as mean ± SD for six animals. Comparisons are made between “a” Group II versus Group I, “b” Group III versus Group II, “c” Group IV versus Group I. The symbol *represents the statistical significance at 𝑃<0.05. NS: nonsignificant.