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International Journal of Hepatology
Volume 2012, Article ID 431761, 5 pages
Review Article

“Human Babesiosis”: An Emerging Transfusion Dilemma

1Department of Physiology, University of Kentucky Medical Center, Lexington, KY 40536, USA
2Department of Internal Medicine, University of Kentucky Medical Center, Lexington, KY 40536, USA

Received 16 December 2011; Accepted 12 January 2012

Academic Editor: Manuela Neuman

Copyright © 2012 Helieh S. Oz and Karin H. Westlund. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Babesiosis, a common disease of animals, can infect humans via vector “tick bite”, particularly in endemic areas. The recent reports of fatal cases in Hepatitis C and postliver transplant patients resulting from transfusion of contaminated blood should alert the medical profession regarding this emerging dilemma in endemic as well as nonendemic areas and the need for accurate blood screening for transfusion. Here, we illustrate different stages of the parasite lifecycle, progression of babesiosis in animal model, some aspects of pathologic outcomes, ongoing therapeutic modalities, and a feasible Acridine Orange fluorescent methodology for the diagnostic evaluation of blood samples.