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International Journal of Hepatology
Volume 2012, Article ID 476910, 9 pages
Review Article

EGFR: A Master Piece in G1/S Phase Transition of Liver Regeneration

1Institut Cochin, Department of Endocrinology Metabolism and Cancer, Université Paris-Descartes, CNRS, UMR8104, 75014 Paris, France
2INSERM, U1016, 75014 Paris, France

Received 21 May 2012; Accepted 11 July 2012

Academic Editor: Anne Corlu

Copyright © 2012 Alexandra Collin de l'Hortet et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Unraveling the molecular clues of liver proliferation has become conceivable thanks to the model of two-third hepatectomy. The synchronicity and the well-scheduled aspect of this process allow scientists to slowly decipher this mystery. During this phenomenon, quiescent hepatocytes of the remnant lobes are able to reenter into the cell cycle initiating the G1-S progression synchronously before completing the cell cycle. The major role played by this step of the cell cycle has been emphasized by loss-of-function studies showing a delay or a lack of coordination in the hepatocytes G1-S progression. Two growth factor receptors, c-Met and EGFR, tightly drive this transition. Due to the level of complexity surrounding EGFR signaling, involving numerous ligands, highly controlled regulations and multiple downstream pathways, we chose to focus on the EGFR pathway for this paper. We will first describe the EGFR pathway in its integrity and then address its essential role in the G1/S phase transition for hepatocyte proliferation. Recently, other levels of control have been discovered to monitor this pathway, which will lead us to discuss regulations of the EGFR pathway and highlight the potential effect of misregulations in pathologies.