CYP2E1 Sensitizes the Liver to LPS- and TNF α-Induced Toxicity via Elevated Oxidative and Nitrosative Stress and Activation of ASK-1 and JNK Mitogen-Activated Kinases
MAP kinase activation. (a) LPS plus pyrazole treatment activates JNK and p38 MAPK. The pJNK/JNK and the pp38 MAPK/p38MAPK ratios are shown below the blots. (b) Either the JNK inhibitor SP600125 (SP) or the p38 MAPK inhibitor SB203508 (SB) prevents TNFα plus pyrazole-induced elevation of ALT and AST or (c) liver pathology.
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