Review Article
Overview of Hepatocellular Adenoma in Japan
Table 1
Clinical and pathological findings of hepatocellular adenoma.
| | | HNF1-inactivated
() | -catenin-activated
() | Inflammatory HCA
() | Unclassified
() |
| | Patients | | | | | | Age; mean ± SD (range) | 40.5 ± 4.9 (37–44) | 28.5 ± 3.5 (26–31) | 40.2 ± 22.8 (15–68) | 33.5 ± 14.1 (16–45) | | Sex (M/F) | 0/2 | 1/1 | 4/1 | 1/3 | | Oral contraceptives | 0 | 0 | 0 | 2 | | Alcohol >40 g/day | 0 | 0 | 2 | 0 | | BMI >25 | 0 | 0 | 2 | 0 | | Other clinical background | Portal hypoplasia 1 | Hyperlipidemia 1 | Diabetes 2 | FAP 1 | | Background liver | | | | | | Steatosis | 0 | 1 | 3 | 2 | | Fibrosis (F1/2/3/4) | 0 | 0 | 3 (2/1/0/0) | 2 (1/1/0/0) | | Tumor | | | | | | Tumor size; mean ± SD (range) | 4.0 ± 1.4 (3–5 cm) | 17.5 ± 2.1* (16–19 cm) | 3.9 ± 2.6 (1.6–9 cm) | 4.4 ± 2.6 (1.5–7 cm) | | Unique/multiple | 1/1 | 2/0 | 3/2 | 1/3 | | Steatosis | 1 | 1 | 2 | 1 | | Association of HCC | 0 | 0 | 0 | 1 |
|
|
HNF1: hepatocyte nuclear factor 1; HCA: hepatocellular adenoma; M: male; F: female; BMI: body mass index; FAP: familial adenomatous polyposis; HCC: hepatocellular carcinoma; *, compared to other groups.
|
