Liver Transplantation and Hepatitis C

Table 1

Factors associated with the severity of recurrent hepatitis C after liver transplantation.

Variables	Effect on recurrent hepatitis C
Donor and graft factors
Age	More severe disease (>40, >50, >65)
Steatosis	Few studies
Prolonged ischemic time	More severe disease
HCV+ graft	No influence
Reduced size versus whole liver (LDLT versus DDLT)	No difference
Pretransplant recipient factors
Genotype 1b	Controversial
Pre-LT higher viral load	Unclear
Age	Few studies
Race	Few studies
Sex	Few studies
HIV coinfection	No influence
IL-28B gene polymorphism	More severe disease in CT and TT genotype
Posttransplant recipient factors
Post-LT higher viral load	More severe disease
CMV infection	Unclear More severe disease
Diabetes mellitus (metabolic syndrome)	More severe disease
Immunosuppression
Steroid bolus	More severe disease
OKT3	More severe disease
Maintenance steroid	Severe disease when rapidly tapered
Steroid free regimen	No influence
Tacrolimus versus Cyclosporine	No difference
Anti-IL-2 receptor antibodies	Controversial
Azathioprine	Controversial
Mycophenolate mofetil	Controversial
mTOR inhibitors	Few studies

Abbreviations: CMV: cytomegalovirus; DDLT: deceased donor liver transplantation; HCV: hepatitis C virus; HIV: human immunodeficiency virus; LDLT: living-donor liver transplantation; LT: liver transplantation; mTOR: mammalian target of rapamycin.