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International Journal of Hepatology
Volume 2012 (2012), Article ID 698905, 6 pages
http://dx.doi.org/10.1155/2012/698905
Research Article

IRS1 Expression in Hepatic Tissue and Leukocytes in Chronic Hepatitis C Virus Infected Patients: A Comparative Study

1Gastroenterology and Hepatology Post-Graduate Course, School of Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
2Experimental Research Center, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil
3Gastroenterology Division, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil

Received 28 February 2012; Revised 18 April 2012; Accepted 4 May 2012

Academic Editor: Helena Cortez-Pinto

Copyright © 2012 Camila Ripoll Kappel et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. Aytug, D. Reich, L. E. Sapiro, D. Bernstein, and N. Begum, “Impaired IRS-1/PI3-kinase signaling in patients with HCV: a mechanism for increased prevalence of type 2 diabetes,” Hepatology, vol. 38, no. 6, pp. 1384–1392, 2003. View at Publisher · View at Google Scholar · View at Scopus
  2. J. M. Hui, A. Sud, G. C. Farrell et al., “Insulin resistance is associated with chronic hepatitis C and virus infection fibrosis progression,” Gastroenterology, vol. 125, no. 6, pp. 1695–1704, 2003. View at Publisher · View at Google Scholar · View at Scopus
  3. F. Negro and M. Alaei, “Hepatitis C virus and type 2 diabetes,” World Journal of Gastroenterology, vol. 15, no. 13, pp. 1537–1547, 2009. View at Publisher · View at Google Scholar · View at Scopus
  4. A. Lonardo, L. E. Adinolfi, S. Petta, A. Craxi, and P. Loria, “Hepatitis C and diabetes: the inevitable coincidence?” Expert Review of Anti-Infective Therapy, vol. 7, no. 3, pp. 293–308, 2009. View at Publisher · View at Google Scholar · View at Scopus
  5. A. Lonardo, N. Carulli, and P. Loria, “HCV and diabetes. A two-question-based reappraisal,” Digestive and Liver Disease, vol. 39, no. 8, pp. 753–761, 2007. View at Publisher · View at Google Scholar · View at Scopus
  6. C. García-Monzón, O. Lo Iacono, R. Mayoral et al., “Hepatic insulin resistance is associated with increased apoptosis and fibrogenesis in nonalcoholic steatohepatitis and chronic hepatitis C,” Journal of Hepatology, vol. 54, no. 1, pp. 142–152, 2011. View at Publisher · View at Google Scholar · View at Scopus
  7. U. Özcan, Q. Cao, E. Yilmaz et al., “Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes,” Science, vol. 306, no. 5695, pp. 457–461, 2004. View at Publisher · View at Google Scholar · View at Scopus
  8. C. M. Taniguchi, K. Ueki, and C. R. Kahn, “Complementary roles of IRS-1 and IRS-2 in the hepatic regulation of metabolism,” Journal of Clinical Investigation, vol. 115, no. 3, pp. 718–727, 2005. View at Publisher · View at Google Scholar · View at Scopus
  9. R. Moucari, T. Asselah, D. Cazals-Hatem et al., “Insulin resistance in chronic hepatitis C: association with genotypes 1 and 4, serum HCV RNA level, and liver fibrosis,” Gastroenterology, vol. 134, no. 2, pp. 416–423, 2008. View at Publisher · View at Google Scholar · View at Scopus
  10. T. Kawaguchi, T. Yoshida, M. Harada et al., “Hepatitis C virus down-regulates insulin receptor substrates 1 and 2 through up-regulation of suppressor of cytokine signaling 3,” American Journal of Pathology, vol. 165, no. 5, pp. 1499–1508, 2004. View at Google Scholar · View at Scopus
  11. T. Kawaguchi, T. Ide, E. Taniguchi et al., “Clearance of HCV improves insulin resistance, beta-cell function, and hepatic expression of insulin receptor substrate 1 and 2,” American Journal of Gastroenterology, vol. 102, no. 3, pp. 570–576, 2007. View at Publisher · View at Google Scholar · View at Scopus
  12. A. Lonardo, L. E. Adinolfi, P. Loria, N. Carulli, G. Ruggiero, and C. P. Day, “Steatosis and hepatitis C virus: mechanisms and significance for hepatic and extrahepatic disease,” Gastroenterology, vol. 126, no. 2, pp. 586–597, 2004. View at Publisher · View at Google Scholar · View at Scopus
  13. A. Mori, P. Lee, T. Sako, H. Mizutani, and T. Arai, “Successful intensive insulin treatment of type 1 diabetic dogs leads to restoration of peripheral leukocyte insulin signaling gene expression and enzyme activities,” Journal of Veterinary Medical Science, vol. 71, no. 8, pp. 1017–1026, 2009. View at Publisher · View at Google Scholar · View at Scopus
  14. A. Mori, P. Lee, H. Takemitsu, T. Sako, and T. Arai, “Comparison of insulin signaling gene expression in insulin sensitive tissues between cats and dogs,” Veterinary Research Communications, vol. 33, no. 3, pp. 211–226, 2009. View at Publisher · View at Google Scholar · View at Scopus
  15. M. Cardellini, R. Menghini, A. Luzi et al., “Decreased IRS2 and TIMP3 expression in monocytes from offspring of type 2 diabetic patients is correlated with insulin resistance and increased intima-media thickness,” Diabetes, vol. 60, no. 12, pp. 3265–3270, 2011. View at Publisher · View at Google Scholar · View at Scopus
  16. T. Poynard, P. Bedossa, and P. Opolon, “Natural history of liver fibrosis progression in patients with chronic hepatitis C,” Lancet, vol. 349, no. 9055, pp. 825–832, 1997. View at Publisher · View at Google Scholar · View at Scopus
  17. P. Bedossa, P. Bioulac-Sage, P. Callard et al., “Intraobserver and interobserver variations in liver biopsy interpretation in patients with chronic hepatitis C,” Hepatology, vol. 20, no. 1 I, pp. 15–20, 1994. View at Publisher · View at Google Scholar · View at Scopus
  18. E. Vanni, M. L. Abate, E. Gentilcore et al., “Sites and mechanisms of insulin resistance in nonobese, nondiabetic patients with chronic hepatitis C,” Hepatology, vol. 50, no. 3, pp. 697–706, 2009. View at Publisher · View at Google Scholar · View at Scopus
  19. J. J. Blonsky and S. A. Harrison, “Review article: Nonalcoholic fatty liver disease and hepatitis C virus—partners in crime,” Alimentary Pharmacology and Therapeutics, vol. 27, no. 10, pp. 855–865, 2008. View at Publisher · View at Google Scholar · View at Scopus
  20. C. P. M. S. Oliveira, C. R. Kappel, E. R. Siqueira et al., “Effects of hepatitis C virus on cardiovascular risk in infected patients: a comparative study,” International Journal of Cardiology. In press. View at Publisher · View at Google Scholar
  21. S. Petta, D. Torres, G. Fazio et al., “Carotid atherosclerosis and chronic hepatitis C: a prospective study of risk associations,” Hepatology, vol. 55, no. 5, pp. 1317–1323, 2012. View at Publisher · View at Google Scholar · View at Scopus
  22. L. E. Adinolfi, L. Restivo, R. Zampino et al., “Chronic HCV infection is a risk of atherosclerosis. Role of HCV and HCV-related steatosis,” Atherosclerosis, vol. 221, no. 2, pp. 496–502, 2012. View at Publisher · View at Google Scholar · View at Scopus
  23. J. A. Del Campo and M. Romero-Gómez, “Steatosis and insulin resistance in hepatitis C: a way out for the virus?” World Journal of Gastroenterology, vol. 15, no. 40, pp. 5014–5019, 2009. View at Publisher · View at Google Scholar · View at Scopus
  24. C. H. Hung, C. M. Lee, C. H. Chen et al., “Association of inflammatory and anti-inflammatory cytokines with insulin resistance in chronic hepatitis C,” Liver International, vol. 29, no. 7, pp. 1086–1093, 2009. View at Publisher · View at Google Scholar · View at Scopus
  25. M. V. Machado and H. Cortez-Pinto, “Insulin resistance and steatosis in chronic hepatitis C,” Annals of Hepatology, vol. 8, no. 1, pp. S67–S75, 2009. View at Google Scholar · View at Scopus
  26. L. Llorente, Y. Richaud-Patin, N. Alcocer-Castillejos et al., “Cytokine gene expression in cirrhotic and non-cirrhotic human liver,” Journal of Hepatology, vol. 24, no. 5, pp. 555–563, 1996. View at Publisher · View at Google Scholar · View at Scopus
  27. M. Eslam, R. Aparcero, T. Kawaguchi et al., “Meta-analysis: Insulin resistance and sustained virological response in hepatitis C,” Alimentary Pharmacology and Therapeutics, vol. 34, no. 3, pp. 297–305, 2011. View at Publisher · View at Google Scholar · View at Scopus
  28. K. L. Milner, D. van der Poorten, M. Trenell et al., “Chronic hepatitis C is associated with peripheral rather than hepatic insulin resistance,” Gastroenterology, vol. 138, no. 3, pp. 932–e3, 2010. View at Publisher · View at Google Scholar · View at Scopus
  29. Y. Shintani, H. Fujie, H. Miyoshi et al., “Hepatitis C virus infection and diabetes: direct involvement of the virus in the development of insulin resistance,” Gastroenterology, vol. 126, no. 3, pp. 840–848, 2004. View at Publisher · View at Google Scholar · View at Scopus
  30. V. Pazienza, S. Clément, P. Pugnale et al., “The hepatitis C virus core protein of genotypes 3a and 1b downregulates insulin receptor substrate 1 through genotype-specific mechanisms,” Hepatology, vol. 45, no. 5, pp. 1164–1171, 2007. View at Publisher · View at Google Scholar · View at Scopus
  31. S. Petta, C. Cammà, V. Di Marco et al., “Insulin resistance is a major determinant of liver stiffness in nondiabetic patients with HCV genotype 1 chronic hepatitis,” Alimentary Pharmacology and Therapeutics, vol. 30, no. 6, pp. 603–613, 2009. View at Publisher · View at Google Scholar · View at Scopus
  32. J. F. Huang, M. L. Yu, C. F. Huang et al., “The outcomes of glucose abnormalities in pre-diabetic chronic hepatitis C patients receiving peginterferon plus ribavirin therapy,” Liver International. In press. View at Publisher · View at Google Scholar