A Complex Interplay between Wnt/β-Catenin Signalling and the Cell Cycle in the Adult Liver
Figure 2
Hypothesis for a crosstalk between β-catenin and Ras signalling pathways to control hepatocyte proliferation. (a) In the quiescent liver, phospho-erk signaling is described as being periportal, while β-catenin is pericentral; (b) no cyclin D1 mRNA is detected in these conditions; (c) 24 h after 2/3 hepatectomy, there is an extension in the β-catenin and the ras activation territories. We now hypothesize that it could generate a common territory in which both which phospho-erk and β-catenin signalings are activated; (d) this can be exemplified by cyclin D1, which is a target of β-catenin, potentiated by ras signaling. Its localization after hepatectomy is restricted to the midlobular region. PV = portal vein; CV = central vein.
