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MRI features |
| Risk factor and clinical setting | T2w | T1w in | T1w out | DWI | Pre-c | ArtP | PVP | EqP | HBP | Specific pattern |
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Inflammatory adenoma | | Hyper | Hypo | Hypo | Restriction | Hypo | Hyper + | Hyper | Hyper/iso | Hypo/hyper | Signal heterogeneity, hypervascularity, intralesional hemorrhage |
HNF-1α-mutated adenoma | Obesity, steatosis, diabetes, glycogenesis, exogenous steroids |
Iso/hyper | Hyper | Hypo | No restriction |
Iso/hypo | Hyper | Hypo | Hypo | Hypo | Fatty intralesional component |
β-catenin-mutated adenoma | Hyper | Hypo | Hypo | Restriction | Hypo | Hyper + | Hyper | Hyper/iso | Hypo/hyper | Intralesional hemorrhage, necrosis |
Unclassified adenoma | | | | | | | | | | | Nonspecific patterns reported |
Focal nodular hyperplasia | Exogenous steroids | Iso | Iso | Iso | No restriction | Iso | Hyper +++ | Iso | Iso |
Iso/hyper | Signal homogeneity, hypervascularity, scar, iso/hyperintensity on HbP |
Large regenerative nodule | Myeloproliferative and lymphoproliferative disorders, chronic vascular and rheumatologic syndromes | Iso | Iso | Iso | No restriction | Iso | Hyper ++ | Iso | Iso |
Iso/hyper | Multiple lesions signal homogeneity, hypervascularity, scar, isohyperintensity on HbP |
HCC in noncirrhotic liver and FL-HCC | Exogenous steroidenvironmental and dietary factors (aflatoxins and nitrosamine) | Hyper | Hypo | Hypo | Restriction | Hypo | Hyper ++ | Hypo | Hypo | Hypo | Signal heterogeneity, intralesional hemorrhage, signs of malignancy |
Cholangiocarcinoma | Viral hepatic infection | Hyper | Hypo | Hypo | Restriction | Hypo | Hyper | Hypo | Hypo/iso | Hypo/hyper | Peripheral enhancement, peripheral washout, central pooling, signs of malignancy |
Primary lymphoma | Epstein-Barr infection (EBV), HBV and/or HCV infections | Iso/hyper | Hypo | Hypo | Restriction | Hypo | Hyper | Hypo | Hypo | Hypo | Variable pattern, small lesions hypervascular, significant restriction |
Metastases | Primary tumor, metastatic syndrome | Hyper | Hypo | Hypo | Restriction | Hypo | Hyper ++ | Iso/hypo | Hypo | Hypo | Multiple lesions hypervascularity, halo signs signs of malignancy |
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