Changing Epidemiology of Hepatocellular Adenoma in the United States: Review of the Literature

Table 2

Published series of hepatocellular adenoma in the United States (1973–1985).

Author; Year of publication; Study duration	𝑛	Sample population	Hormonal therapy (%)	Women (%)	Mean age	Single	Multiple	Presenting symptoms	Hemorrhage	Malignancy	Treatment
Mays and Christopherson [18]; 1984; (1973–1984)	71	Single-center surgical registry	83%	100%	30	NR	NR	(36.6%) mass; (31%) hemoperitoneum; (24%) pain; (5.6%) incidental; (2.8%) unknown	NR	NR
Weil et al. [19]; 1979; (1970–1978)	8	Single-center surgical series	4 (50%)	7 (88%)	24	8 (100%)	0	6 fever; 6 abdominal pain; 3 palpable abdominal mass	4 (50%)	0	Resection
Bourne Rooks; et al. [20]; 1979; (1957–1976)	79	Database of pathology referrals	73 (92%)	79 (100%)	30.4	NR	NR	34% intraperitoneal bleeding; 15% intratumoral hemorrhage; 47% abdominal mass; 19% abdominal pain	49%	0	Resection
Edmondson et al. [21]; 1976; (1955–1976)	42	Single-center surgical series	31/36^1 (86%)	42 (100%)	NR	NR	NR	12 (28%) pain; 18 (43%) palpable mass; 2 (4.7%) incidental	10 (24%)	0	41 resection
Ameriks et al. [22]; 1975; (1969–1973)	8	Single-center surgical series	8 (100%)	8 (100%)	33.6	7	1	3 hemoperitoneum; 3 abdominal pain, intrahepatic hemorrhage; 3 palpable mass	6 (75%)	0	Resection
Baum et al. [23]; 1973	7	Case series	7 (100%)	7 (100%)	28.7	7	0	5 abdominal pain; 2 right upper quadrant mass	5	0	Resection

NR: not reported.
¹Data on OCP use not available in 6 cases.