Research Article
Pathogenic Role of Iron Deposition in Reticuloendothelial Cells during the Development of Chronic Hepatitis C
Table 2
Logistic regression analysis of factors associated with advanced stage.
| | Stage 0–2 | Stage 3–4 | Univariate | Multivariate |
| Age | 54.2 ± 12.1 | 59.3 ± 9.9 | 0.019 | 0.968 | Gender (male/female) | 136/172 | 35/30 | 0.099* | — | BMI (kg/m2) | 22.4 ± 3.1 | 26.6 ± 5.0 | <0.000005 | 0.450 | Diabetes (yes/no) | 20/288 | 11/54 | 0.009* | 0.072 | Genotype (1a/1b/2a/2b/3a) | 3/159/46/26/1 | 2/31/11/2/0 | 0.350* | — | Serogroup (G1/G2) | 56/17 | 13/6 | 0.469* | — | HCV-RNA (logIU/mL) | 6.0 ± 0.8 | 6.3 ± 0.7 | 0.536 | — | AST (IU/L) | 48.4 ± 33.7 | 80.9 ± 40.9 | <0.0000001 | <0.05 | ALT (IU/L) | 64.9 ± 59.5 | 90.2 ± 52.7 | <0.0000001 | <0.05 | IRI (μU/mL) | 9.0 ± 6.4 | 14.9 ± 10.6 | 0.008 | 0.151 | FPG (mg/dL) | 100.2 ± 26.4 | 110.2 ± 31.8 | <0.0001 | 0.675 | HOMA-R | 2.5 ± 3.9 | 4.7 ± 6.4 | 0.040 | 0.324 | Ferritin (ng/mL) | 214.1 ± 235.3 | 221.2 ± 185.8 | 0.034 | <0.05 | Grade (0/1/2/3) | 6/177/115/10 | 0/2/39/24 | <0.0000001* | <0.005 | Steatosis (0/1/2/3) | 188/78/37/5 | 16/22/18/9 | <0.0000001* | 0.811 | HC iron (0/1/2/3/4) | 139/76/57/28/8 | 26/17/17/3/2 | 0.511* | — | REC iron (0/1/2) | 223/60/25 | 25/28/12 | <0.0000005* | <0.05 |
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BMI: body mass index, AST: aspartate aminotransferase, ALT: alanine aminotransferase, IRI: immunoreactive insulin, FPG: fasting plasma glucose, HOMA-R: homeostasis model assessment ratio, HC: hepatocytes, and REC: reticuloendothelial cells. Univariate: Student's -test, Multivariate: logistic regression, and *Chi-squared test.
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