Research Article

Pathogenic Role of Iron Deposition in Reticuloendothelial Cells during the Development of Chronic Hepatitis C

Table 2

Logistic regression analysis of factors associated with advanced stage.

Stage 0–2Stage 3–4UnivariateMultivariate

Age54.2 ± 12.159.3 ± 9.90.0190.968
Gender (male/female)136/17235/300.099*
BMI (kg/m2)22.4 ± 3.126.6 ± 5.0<0.0000050.450
Diabetes (yes/no)20/28811/540.009*0.072
Genotype (1a/1b/2a/2b/3a)3/159/46/26/12/31/11/2/00.350*
Serogroup (G1/G2)56/1713/60.469*
HCV-RNA (logIU/mL)6.0 ± 0.86.3 ± 0.70.536
AST (IU/L)48.4 ± 33.780.9 ± 40.9<0.0000001<0.05
ALT (IU/L)64.9 ± 59.590.2 ± 52.7<0.0000001<0.05
IRI (μU/mL)9.0 ± 6.414.9 ± 10.60.0080.151
FPG (mg/dL)100.2 ± 26.4110.2 ± 31.8<0.00010.675
HOMA-R2.5 ± 3.94.7 ± 6.40.0400.324
Ferritin (ng/mL)214.1 ± 235.3221.2 ± 185.80.034<0.05
Grade (0/1/2/3)6/177/115/100/2/39/24<0.0000001*<0.005
Steatosis (0/1/2/3)188/78/37/516/22/18/9<0.0000001*0.811
HC iron (0/1/2/3/4)139/76/57/28/826/17/17/3/20.511*
REC iron (0/1/2)223/60/2525/28/12<0.0000005*<0.05

BMI: body mass index, AST: aspartate aminotransferase, ALT: alanine aminotransferase, IRI: immunoreactive insulin, FPG: fasting plasma glucose, HOMA-R: homeostasis model assessment ratio, HC: hepatocytes, and REC: reticuloendothelial cells.
Univariate: Student's -test, Multivariate: logistic regression, and *Chi-squared test.