Quantification of Pregenomic RNA and Covalently Closed Circular DNA in Hepatitis B Virus-Related Hepatocellular Carcinoma
Table 2
Clinical characteristics of patients.
HBsAg-positive carriers ()
HBsAg−/HBcAb+ patients ()
value
Male/female
13/1
21/3
NS
Age (years)
55.7 ± 12.0
68.7 ± 9.3
0.002
BMI
20.5 ± 3.7
23.1 ± 3.4
NS
Prevalence of BMI >22
3/14 (21%)
14/24 (58%)
0.03*
Platelet count (/mm3)
18.1 ± 4.0
19.3 ± 8.4
NS
Albumin (g/dL)
4.2 ± 0.6
3.9 ± 0.6
NS
AST (IU/L)
30.3 ± 5.9
74.0 ± 59.6
NS
HbA1c
5.04 ± 0.33
5.96 ± 0.87
<0.001
ICG-R 15 (%)
9.54 ± 2.76
11.15 ± 5.22
NS
Child-Pugh (A/B/C)
13/1/0
18/3/0
NS
HBV-DNA > 4 log copies/mL
6 (42.9)
0 (0.0)
0.012
Genotype B/C
1/13
0/17
NS
AFP > 200 (ng/mL)
7 (50%)
8 (33.3%)
NS
PIVKA-II > 400 (mAU/mL)
9 (64.3%)
14 (58.3%)
NS
Stage I/II/III/IV
1/4/2/3
1/6/2/9
NS
AST: aspartate aminotransferase; AFP: α-fetoprotein; PIVKA-II: protein induced by vitamin K absence or antagonist II; NS: not significant.
*Mann-Whitney’s test.
