Quantification of Pregenomic RNA and Covalently Closed Circular DNA in Hepatitis B Virus-Related Hepatocellular Carcinoma

Table 3

Detection of HBV-DNA in 24 HCC patients with HBsAg-negative and HBcAb-positive patients.

	Cancerous tissue	Noncancerous tissue	𝑃 value
S region	9 (38%)	17 (71%)	0.020
Precore-core region	4 (17%)	4 (17%)	NS
Polymerase region	14 (58%)	10 (42%)	NS
X region	12 (50%)	21 (88%)	0.005
Positive in ≥2 regions	10 (42%)	20 (83%)	0.003

NS: not significant.