Review Article
Intraductal Papillary Neoplasms of the Bile Duct
Table 2
Molecular events in the intraductal papillary neoplasms of the bile duct lineage and the biliary intraepithelial neoplasia lineage.
| | Authors | Cyclin D1 | p16 | c-myc | -catenin | SMAD4/DPC4 | p53 | | IPNB | BilIN | IPNB | BilIN | IPNB | BilIN | IPNB | BilIN | IPNB | BilIN | IPNB non-inv. | IPNB inv. | BilIN non-inv. | BilIN inv. |
| | Itatsu et al. [34] | 65 (17)* | 20 (45) | N.D. | 54 (13) | 13 (45) | 22 (18) | 0 (45) | N.D. | N.D. | | Nakanishi et al. [35] | 53 (10) | 43 (11) | N.D. | N.D. | N.D. | 21 (36) | 27 (49) | 38 (16) | 36 (10) | 8 (38) | 82 (11) | |
Schlitter et al. [36] | N.D. | 24 (42) | 36 (22) | N.D. | 9 (45) | 0 (22) | 7 (45) | 14 (22) | 60 (52) | 85 (13) | N.D. | 64 (22) | | Sasaki et al. [37] | N.D. | 29 (34) | N.D. | N.D. | N.D. | N.D. | 0 (15) | 30 (19) | N.D. | | Abraham et al. [38] | N.D. | N.D. | N.D. | 25 (12) | N.D. | 0 (12) | N.D. | 0 (12) | N.D. |
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*% of cases with positive staining or mutations (total cases examined); N.D.: not determined; inv.: invasive.
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