Research Article
Serum Cytokeratin-18 Is Associated with NOX2-Generated Oxidative Stress in Patients with Nonalcoholic Fatty Liver
Table 2
Clinical and biochemical characteristics of 209 subjects with NAFLD divided by serum cytokeratin-18 tertiles.
| | | Cytokeratin-18 tertiles | | | | I | II | III |
| | Males (%) | 68.1 | 63.0 | 62.7 | ns | | Age (yrs) | | | | ns | | Body mass index (kg/m2) | | | | <0.001 | | Urinary 8-iso-PGF2α (pg/mg creatinine) | | | | <0.001 | | HOMA-IR | 2.8 (1.9/4.0) | 3.2 (2.4/5.7) | 5.3 (3.4/7.3) | <0.001 | | Total cholesterol (mg/dL) | | | | ns | | HDL (mg/dL) | 50 (43/61) | 47 (38/54) | 43 (39/51) | <0.05 | | Triglycerides (mg/dL) | 125.5 (85.5/160.3) | 138 (102.0/180.5) | 165.0 (125.0/206.0) | <0.01 | | -GT (IU/L) | 23 (16.8/36.5) | 27 (17.5/44.0) | 30 (18/53) | ns | | ALT (IU/L) | 31 (22.8/40) | 28 (20/41.5) | 26 (20/40) | ns | | AST (IU/L) | 22 (18/28) | 21 (17/26.5) | 21 (17/28) | ns | | Adiponectin (ng/mL) | 12 (10.4/14.1) |
7.5 (5.5/10.5) | 5 (4/7) | <0.001 | | sNOX2-dp (pg/mL) | 49 (40/58.3) | 60 (50/66) | 67 (64/71) | <0.001 | | Hamaguchi score | | | | <0.01 | | Metabolic syndrome (%) | 49.4 | 69.0 | 84.8 | <0.001 | | Diabetes (%) | 20.3 | 30.1 | 43.3 | <0.05 |
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