Evaluation of Serum Cystatin C as a Marker of Early Renal Impairment in Patients with Liver Cirrhosis

Table 1

GFR-estimating equations used in the study.

Cockcroft-Gault formula	140 – age (years) × weight (kg)/(Scr × 72) × 0.85 if female
MDRD equations using 4 variables	186 × Scr^−1.154  × age (years)^−0.203  × 0.742 if female × 1.212 if black
MDRD equations using 6 variables	170 × Scr^−0.999  × age (years)^−0.176  × BUN (mg/dL)^−0.170  × albumin (g/dL)^0.318  × 0.762 if female × 1.180 if black
The CKD-EPI creatinine equation	141 × min(Scr/κ, 1)^α  × max(Scr/κ, 1)^−1.209  × 0.99 [×1.018 if female] [×1.159 if black], where α is −0.329 for females and −0.411 for males
The CKD-EPI cystatin C equation	133 × min(Scys/0.8, 1)^−0.499  × max(Scys/0.8, 1)^−1.328  × [×0.932 if female]
The CKD-EPI creatinine–cystatin C equation	135 × min(Scr/κ, 1)^α  × max(Scr/κ, 1)^−0.601  × min(Scys/0.8, 1)^−0.375  × max(Scys/0.8, 1)^−0.711  × [×0.969 if female] [×1.08 if black], where α is −0.248 for females and −0.207 for males

κ is 0.7 for females and 0.9 for males, max is the maximum of Scr/κ or 1, min is the minimum of Scr/κ or 1, Scr is serum creatinine in (mg/dL), and Scys is serum cystatin C in (mg/L).