A Combination of Leucine, Metformin, and Sildenafil Treats Nonalcoholic Fatty Liver Disease and Steatohepatitis in Mice
Sild-Met-Leu effects on liver weight, liver triglycerides, and ALT in mice. Mice were fed a low-fat (LF) diet or high-fat atherogenic (HC) diet for 6 weeks and then randomized to the indicated treatment groups for an additional 6 weeks. (a) Liver weight (expressed as ratio to total body weight), (b) liver triglycerides, and (c) alanine aminotransferase (ALT) were determined at the end of the study. Data are expressed as mean ± SEM ( to 8). Sild: sildenafil, Met: metformin, Leu: leucine.