Development of NASH in Obese Mice is Confounded by Adipose Tissue Increase in Inflammatory NOV and Oxidative Stress

Table 1

Histopathological NAS score evaluation. Degree of steatosis and NASH (grade 0 ≤ 5%; 1 = 5–33%; grade 2 = 34%–66%; grade 3 ≥ 66%), lobular inflammation (0: no foci, 1 < 2 foci per 200x field, 2: 2 to 4 foci per 200x field, and 3: foci per 200x field), hepatocyte ballooning (0: none; 1: rare or few; 2: many), and fibrosis (0: no fibrosis, 1: perisinusoidal or periportal fibrosis, 2: perisinusoidal and portal/perioral fibrosis, 3: bridging fibrosis, and 4: cirrhosis).

NAS pathological score factors	Control	HF	HF + CoPP	HF + CoPP + SnMP
Steatosis	0 (0.67%)	2 (42.24%)	1 (10.28%)	2 (33.05%)
Inflammation	0 (no foci)	2 (2-4 foci/field)	1 (<2 foci/field)	2 (2-4 foci/field)
Ballooning	1 (rare)	2 (many)	1 (rare)	2 (many)
Fibrosis	0 (no fibrosis)	3 (bridging fibrosis)	0 (no fibrosis)	2 (perisinusoidal and portal fibrosis)
NAS value	1	9 NASH	3	8 NASH