Preoperative Neutrophil-to-Lymphocyte Ratio Plus Platelet-to-Lymphocyte Ratio Predicts the Outcomes after Curative Resection for Hepatocellular Carcinoma

Table 4

Clinicopathological characteristics of patients undergoing curative hepatectomy for HCC.

Clinical variables	NLR-PLR 0	NLR-PLR 1	NLR-PLR 2	p
	n = 64 (49%)	n = 32 (24%)	n = 36 (27%)
Patient factors
Male (n, %)	55 (85.9%)	29 (90.6%)	32 (88.9%)	0.78
Age(years; mean ± SD)	64.5±8.9	67.8±8.8	63.9±12.6	0.24
Hepatitis B (n, %)	39 (60.9.%)	18 (56.2%)	18 (50.0%)	0.57
Child-Pugh Class B (n, %)	1 (1.6)	3 (9.4%)	9 (25.0%)	<0.01
Laboratory data
ICG>15 (n, %)	21 (32.8%)	7 (21.9%)	2 (5.6%)	0.01
Creatinine (mean ± SD)	104±133	95±43	87±101	0.69
Surgical factors
Major hepatectomy (n, %)	26 (40.6%)	12 (37.5%)	23 (63.9%)	0.04
Operation time >350min (n, %)	21 (32.8%)	7 (21.9%)	15 (41.7%)	0.22
EBL >500ml (n, %)	37 (57.8%)	19(59.4%)	25 (69.4%)	0.50
Tumor factors
AFP >400ug/L (n, %)	11 (20.8%)	6 (18.8%)	1 (2.7%)	0.08
Tumor size >5 (n, %)	20 (31.2%)	12 (37.5%)	28(77.8%)	<0.01
Multiple tumors (n, %)	12 (18.8%)	10 (31.2%)	8 (22.2%)	0.38
R1 resection (n, %)	4 (6.2%)	2 (6.2%)	7 (19.4%)	0.08
Postoperative factors
Wound infection	2 (3.1%)	3 (9.4%)	1 (2.8%)	0.32
Pneumonia	10 (15.6%)	5 (15.6%)	7 (19.4%)	0.87
UTI	3 (4.7%)	3 (9.4%)	1 (2.8%)	0.46
Bile leak	0 (0)	0 (0)	2 (5.6%)	0.07
Intra-abdominal collection	2 (3.1%)	0 (0)	2 (5.6%)	0.41
Liver failure	4 (6.2%)	3 (9.4%)	4 (11.1%)	0.68
Follow-up
30-day mortality	2 (3.1%)	1 (3.1%)	0 (0)	0.52
LOS (days, mean ± SD)	11.2±11.6	13.4±20.6	19.7± 26.2	0.22
OS (months, median [IQR])	26.5 (11-48)	19.5 (5-36)	24.5 (7-37)	0.02
RFS (months, median [IQR])	20 (7-40.5)	12 (5-25)	14.5 (4-28)	0.02

NLR: neutrophil-to-lymphocyte ratio; PLR: platelet-to-lymphocyte ratio; ICG: indocyanine green; EBL: estimated blood loss; AFP: a-fetoprotein; UTI: urinary tract infection; LOS: length of stay; OS: overall survival; RFS: recurrence free survival; IQR: interquartile range; SD: standard derivation.