Hepatocellular Expression of SIRT1 and Its Effect on Hepatocellular Carcinoma Progression: A Future Therapeutic Perspective

Figure 3

The therapeutic role of SIRT1 inhibition in HCC treatment. Inhibition of SIRT1 by different small molecules results in the activation and inactivation of tumor suppressor and oncogenes, respectively. This further results in a good chemotherapeutic treatment outcome of the disease, slowdown of the progression, and stimulation of apoptosis of HCC cells.