International Journal of Hepatology

Benign Hepatocellular Tumors: A Multidisciplinary Approach

Publishing date
08 Mar 2013
Submission deadline
26 Oct 2012

1Department of Pathology, Bordeaux University Hospital, Bordeaux, France; Inserm U1053, Bordeaux Segalen University, Bordeaux, France

2Department of Radiology, University of Brescia, Brescia, Italy

3Department of Surgery, Erasmus University Medical Center, Rotterdam, The Netherlands

4The Mount Sinai Medical Center, New York, NY 10029, USA

Benign Hepatocellular Tumors: A Multidisciplinary Approach


Focal nodular hyperplasia and hepatocellular adenomas are benign solitary or multiple hepatocellular tumors with different outcomes. It is, therefore, important to differentiate these two types of tumors. So far the risk of HCA bleeding and malignant transformation into hepatocellular carcinoma is based only on size. Molecular signature of HCA subtypes has permitted to better divide FNH from HCA and HCA from HCC and to identify HCA subtypes with different risks of HCC transformation. These advances have allowed to individualize HCA subtypes by immunohistochemistry on liver biopsy and to recognize the 2 major subtypes by imaging. HCA and FNH are thought to occur on the same background, but this is much too restrictive. Due to the rarity of HCA, it has not been possible to set up a consensus regarding treatment and followup of patients with benign hepatocellular tumors.

We invite investigators to contribute original research as well as review articles that will take into account the identification of FNH and HCA subtypes particularly those at risk of bleeding and malignant transformation, the circumstances and mechanisms leading to the formation of FNH and HCC, and the rational therapeutic and follow-up modalities . Potential topics include, but are not limited to:

  • Molecular biology of FNH and HCA
  • Identification of FNH and HCA by modern imaging technics
  • Identification and management of HCA (solitary and multiple) at risk of bleeding and bleeding
  • Identification and management of HCA (solitary and multiple) at risk of malignancy and with malignant transformation
  • Radiological followup of unresected FNH and HCA
  • Vascular involvement in the genesis of FNH and HCA
  • Genetic (constitutional) diseases leading to HCA
  • HCA and pregnancy

Before submission authors should carefully read over the journal's Author Guidelines, which are located at Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at according to the following timetable:

International Journal of Hepatology
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