The Relationship between the Transforming Growth Factor 𝛽1 T29C Gene Polymorphism and Left Ventricular Geometry and Function in Hypertensive Subjects

Table 3

Renal measurements, Circulating TGF𝛽1 and Pro-collagen III in hypertensives with left ventricular hypertrophy subgrouped according to Leu¹⁰→Pro¹⁰ TGF𝛽1 genotypes.

	TT n. 30	TC n. 128	CC n. 40
BUN (mg/dL)	39 ± 6	38 ± 7	39 ± 8
Creatinine (𝜇mol/L)	61.9 ±17.7	79.6 ± 17.7	79.6 ± 17.7
Clearance (mL/min)	108 ± 30	103 ± 38	102 ± 32
UAE (mg/24h)	51 ± 40	113 ± 36*	92 ± 69*
Microalbuminuric	5/30	80/128	21/40
pts (%)	(16.7%)	(62.5%)*	(52.5%)*
TGF𝛽1 (ng/mL)	45 ± 22	60 ± 15*	58 ± 11*
PIIIP (U/L)	0.60 ± 0.1	0.71 ± 0.1*	0.65 ± 0.1*

BUN: Blood urea nitrogen; TGF𝛽1: Transforming growth factor 𝛽1; PIIIP: amino-terminal propeptide of type III procollagen; UAE: Urinary albumin excretion; pts: patients.
^∗𝑃<.05 versus TT.