Genome-Wide Association Study of Coronary Artery Disease

Table 1

The well-known genetic polymorphisms which are thought to be associated with myocardial infarction or coronary artery disease.

Location	Gene name/Polymorphisms
17q23	Angiotensin-Converting Enzyme insertion/deletion (intron 16)
1q42-q43	Angiotensinogen Met235Thr, −6G/A
3q21-q25	Angiotensin II type1 Receptor 1166A/C
8q21-q22	Aldosterone Synthase (CYP11B2) −344T/C, Lys173Arg
14q32.1-q32.2	Bradykinin B2 receptor gene −58T/C
6p24.1	Endothelin-1 Lys198Asn
7q36	eNOS Glu298Asp, −786T/C
17q21.32	Glycoprotein IIIa P1A1/A2
5q23-31	Glycoprotein Ia 807T/C
17pter-p12	Glycoprotein Ibα Thr145Met
4q28	βfibrinogen −455G/A
11p11-q12	Prothrombin 20210G/A
7q21.3-q22	PAI-1 4G/5G (promoter region)
7q21.3	Paraoxonase1 Arg192Gln, Leu54Met
8p12-p11.2	Werner Helicase Gene Cys1367Arg
1p36.3	Methylenetetrahydrofolate reductase 677C/T
16q24	NADH/NADPH oxidase p22phox 242C/T, 640A/G
5q31.1	CD14 Monocyte Receptor −260C/T
11q22.3	Stromelysin (MMP3) 5A/6A (promoter region)
20q11.2-q13.1	Gelatinase B (MMP9) −1562C/T
19q13.2	ApolipoproteinE E2/E3/E4
16q21	Cholesteryl Ester Transfer Protein (CETP) Ile405Val
9q31.1	ABCA1 gene Ile823Met
3p25	PPAR-gamma Pro12Ala, Pro115Gln
20q13.11-q13.13	Prostacyclin synthase gene
The number of 9-bp (CCGCCAGCC) repeats (promoter region)
17q11.2-q21.1	MCP-1 −2518G/A