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International Journal of Hypertension
Volume 2011 (2011), Article ID 132405, 9 pages
Review Article

Hypertension in Chronic Kidney Disease: Navigating the Evidence

1Division of Renal Diseases, Department of Medicine, SUNY Downstate Medical Center, 450 Clarkson Avenue, Box 52, Brooklyn, NY 11203, USA
2Department of Medicine, Brooklyn Health Disparities Center, SUNY Downstate Medical Center, Brooklyn, NY 11203, USA

Received 14 February 2011; Accepted 29 March 2011

Academic Editor: Adam T. Whaley-Connell

Copyright © 2011 F. M. Tedla et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Hypertension is both an important cause and consequence of chronic kidney disease. Evidence from numerous clinical trials has demonstrated the benefit of blood pressure control. However, it remains unclear whether available results could be extrapolated to patients with chronic kidney diseases because most studies on hypertension have excluded patients with kidney failure. In addition, chronic kidney disease encompasses a large group of clinical disorders with heterogeneous natural history and pathogenesis. In this paper, we review current evidence supporting treatment of hypertension in various forms of chronic kidney disease and highlight some of the gaps in the extant literature.